DYRK3 Protein, Human, Recombinant (GST)

Name: DYRK3 Protein, Human, Recombinant (GST)
Brand: TargetMol
SKU: TMPC-00209
Rating: 4.5 (1 reviews)

(Synonyms: Regulatory erythroid kinase, REDK, DYRK3, Dual specificity tyrosine-phosphorylation-regulated kinase 3) Copy Product Info

Synonyms: Regulatory erythroid kinase, REDK, DYRK3, Dual specificity tyrosine-phosphorylation-regulated kinase 3

Catalog No. TMPC-00209 Copy Product Info

DYRK3 Protein, Human, Recombinant (GST) is expressed in E. coli. The accession number is O43781.

Pack Size	Price	USA Stock	Global Stock	Quantity
10 µg	$1,390	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	The specific activity of DYRK3 was determined to be 285-330 nmol /min/mg by ADP-Glo kinase assay.
Description	DYRK3 Protein, Human, Recombinant (GST) is expressed in E. coli. The accession number is O43781.
Species	Human
Expression System	E. coli
Tag	N-GST
Accession Number	O43781
Construction	Recombinant human DYRK3 (63-end) was expressed in E. coli cells using an N-terminal GST tag.
Protein Purity	>70% as determined by SDS-PAGE.
Formulation	Supplied as sterile 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Synonyms	Regulatory erythroid kinase, REDK, DYRK3, Dual specificity tyrosine-phosphorylation-regulated kinase 3
Research Background	Dual specificity tyrosine-phosphorylation-regulated kinase 3, also known as Regulatory erythroid kinase, REDK and DYRK3, is a nucleus protein which belongs to theprotein kinase superfamily, CMGC Ser/Thr protein kinase family and MNB/DYRK subfamily. DYRKs are an emerging family of dual-specificity kinases that play key roles in cell proliferation, survival, and development. DYRK3 contains oneprotein kinase domain. Isoform 1 and isoform 2 of DYRK3 are highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow. Isoform 2 of DYRK3 is the predominant form in testis. Isoform 1 of DYRK3 is the predominant form in fetal liver and bone marrow. Isoform 1 and isoform 2 are present at low levels in heart, pancreas, lymph node, and thymus. DYRK3 is a negative regulator of EPO-dependent erythropoiesis. It may place an upper limit on red cell production during stress erythropoiesis. DYRK3 inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. It may also act by regulating CREB/CRE signaling. DYRK3 proved to effectively inhibit NFAT (nuclear factor of activated T cells) transcriptional response pathways and to co-immunoprecipitate with NFATc3. DYRK3 attenuates (and possibly apportions) red cell production selectively during anemia.

Chemical Properties

Molecular Weight

~95 kDa

Storage & Solubility Information

Shipping	Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.