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Carbonic Anhydrase 9 Protein, Human, Recombinant (hFc & Avi), Biotinylated
(Synonyms: MN, Carbonic Anhydrase IX, CAIX) Copy Product InfoSynonyms: MN, Carbonic Anhydrase IX, CAIX
Catalog No. TMPY-06939 Copy Product Info
Carbonic Anhydrase 9 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 69.51 kDa and the accession number is NP_001207.2.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $215 | 7-10 days | 7-10 days | |
| 10 µg | $359 | 7-10 days | 7-10 days | |
| 20 µg | $600 | 7-10 days | 7-10 days | |
| 50 µg | $939 | 7-10 days | 7-10 days | |
| 100 µg | $1,580 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | 1.Immobilized Anti-CA9 (Girentuximab biosimilar) at 2 μg/mL (100 μL/well) can bind Recombinant Human Carbonic Anhydrase IX Protein (Fc & Avi Tag),Biotinylated (Cat#TMPY-06939), the EC50 is 0.8-3 ng/mL(QC tested). 2.Immobilized Recombinant Human Carbonic Anhydrase IX Protein (Fc & Avi Tag), Biotinylated (Cat#TMPY-06939) at 1 μg/mL (100 μL/well) on Streptavidin precoated (5 μg/mL, 100 μL/well) plate can bind anti-CA9 (Girentuximab biosimilar), the EC50 is 4.3 ng/mL (Routinely tested). |
| Description | Carbonic Anhydrase 9 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 69.51 kDa and the accession number is NP_001207.2. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-hFc-Avi |
| Accession Number | NP_001207.2 |
| Construction | A DNA sequence encoding the Human CA9 (NP_001207.2)(Met1-Asp414) was expressed with a c-terminal AVI tagged Fc region of human IgG1 at the C-terminus (Fc-AVI). The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed. Predicted N terminal: Gln 38 |
| Protein Purity | ≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC. |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Synonyms | MN, Carbonic Anhydrase IX, CAIX |
| Research Background | Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide (H2O + CO2 = H+ + HCO3–) and thus participate in a variety of biological and physical processes. CA IX protein is expressed primarily in carcinoma cells lines, and the expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. It is involved in tumorigenesis through many pathways, such as pH regulation and cell adhesion control. CA IX is used as a marker of tumor hypoxia and as a new therapeutic target for many human carcinomas and cancers.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Molecular Weight | 69.51 kDa (predicted); 82.1 kDa (reducing conditions) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: Carbonic Anhydrase 9 Protein, Human, Recombinant (hFc & Avi), Biotinylated chemical structure | Carbonic Anhydrase 9 Protein, Human, Recombinant (hFc & Avi), Biotinylated molecular weight
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