LEPR Protein, Mouse, Recombinant (hFc)

Name: LEPR Protein, Mouse, Recombinant (hFc)
Brand: TargetMol
SKU: TMPJ-00975
Rating: 4.5 (1 reviews)

(Synonyms: OB-R, OBR, OB receptor, Leptin receptor, LEP-R, LEPR, HuB219, DB, CD295) Copy Product Info

Synonyms: OB-R, OBR, OB receptor, Leptin receptor, LEP-R, LEPR, HuB219, DB, CD295

Catalog No. TMPJ-00975 Copy Product Info

LEPR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 130-190 KDa and the accession number is P48356.

Pack Size	Price	USA Stock	Global Stock
5 µg	$58	35 days	35 days
10 µg	$91	35 days	35 days
20 µg	$146	35 days	35 days
50 µg	$278	35 days	35 days
100 µg	$473	35 days	35 days
200 µg	$813	35 days	35 days
500 µg	$1,670	35 days	35 days
1 mg	$2,510	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	LEPR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 130-190 KDa and the accession number is P48356.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	P48356
Amino Acid	Leu22-Gly839
Construction	Leu22-Gly839
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	OB-R, OBR, OB receptor, Leptin receptor, LEP-R, LEPR, HuB219, DB, CD295
Research Background	The Leptin receptor is a member of the Class I cytokine receptor family. It mediates the activities of Leptin, a multi-functional hormone produced primarily by adipose tissues that plays roles in food intake, energy metabolism, angiogenesis, reproduction, hematopoiesis, bone metabolism, and immune function. The human Leptin R gene encodes 1165 amino acids (aa) including a signal peptide, an extracellular region with cytokine receptor homology (CRH), multiple fibronectin type III domains and a WSXWS motif, a transmembrane domain, and a cytoplasmic domain that supports JAK/STAT signaling. Soluble Leptin R is the primary Leptin-binding protein in blood, where it maintains a pool of available bioactive Leptin, delays Leptin clearance from circulation, and down-regulates blood-brain transmission of Leptin. In humans, soluble Leptin R levels are inversely proportional to adiposity and are elevated in females versus males. Soluble Leptin R is also found up-regulated in patients with chronic heart failure, end-stage renal disease, and anorexia.It is expressed by tumor-initiating stem cells, and is proposed as a link between cancer and obesity.

Chemical Properties

Molecular Weight

130-190 KDa (reducing condition)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.