CD40 Protein, Human, Recombinant (mFc)

Name: CD40 Protein, Human, Recombinant (mFc)
Brand: TargetMol
SKU: TMPY-05359
Rating: 4.5 (1 reviews)

(Synonyms: TNFRSF5, p50, CDW40, CD40 molecule, TNF receptor superfamily member 5, Bp50) Copy Product Info

Synonyms: TNFRSF5, p50, CDW40, CD40 molecule, TNF receptor superfamily member 5, Bp50

Catalog No. TMPY-05359 Copy Product Info

CD40 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 45.5 kDa and the accession number is NP_001309350.1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$53	7-10 days	7-10 days
10 µg	$85	7-10 days	7-10 days
20 µg	$138	7-10 days	7-10 days
50 µg	$258	7-10 days	7-10 days
100 µg	$520	7-10 days	7-10 days
200 µg	$819	7-10 days	7-10 days
500 µg	$1,720	7-10 days	7-10 days
1 mg	$3,790	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Information

Bioactivity

Bioactivity	Loaded Human CD40L-His on HIS1K Biosensor, can bind Human CD40-mFc with an affinity constant of 0.20 uM as determined in BLI assay.
Description	CD40 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 45.5 kDa and the accession number is NP_001309350.1.
Species	Human
Expression System	HEK293 Cells
Tag	C-mFc
Accession Number	P25942
Construction	Glu21-Arg193
Protein Purity	> 95 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	TNFRSF5, p50, CDW40, CD40 molecule, TNF receptor superfamily member 5, Bp50
Research Background	CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

45.7 kDa (predicted); 50-65 kDa (reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.