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Claudin-18.1 Protein, Human, Recombinant (His)

Catalog No. TMPJ-01026
Synonyms: CLDN18, Claudin-18

Claudin-18.1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-8xHis tag. The predicted molecular weight is 18 KDa and the accession number is P56856.

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Claudin-18.1 Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 310.00
50 μg 5 days $ 669.00
500 μg 5 days $ 2,730.00
1 mg 5 days $ 4,370.00
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Biological Description
Technical Params
Product Properties
Description Claudin-18.1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-8xHis tag. The predicted molecular weight is 18 KDa and the accession number is P56856.
Species Human
Expression System E. coli
Tag N-8His
Accession Number P56856
Synonyms CLDN18, Claudin-18
Amino Acid Asp28-Leu76
Construction Recombinant Human CLDN18.1 is produced by our E.coli expression system and the target gene encoding Asp28-Leu76 is expressed with a 8His tag at the N-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 18 KDa, reducing conditions
Endotoxin Less than 1 EU/µg as determined by LAL test.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 8% Sucrose, 2% Glycine, 20% Glycerol, 5mM DTT, 0.05% Tween 80, pH 8.0.
Stability & Storage

Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Shipping

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

Research Background Claudin-18(CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.

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Keywords

Claudin-18.1 Protein, Human, Recombinant (His) CLDN18 CLDN 18 CLDN-18 Claudin-18 recombinant recombinant-proteins proteins protein

 

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