AXL Protein, Human, Recombinant (mFc)

Name: AXL Protein, Human, Recombinant (mFc)
Brand: TargetMol
SKU: TMPY-06478
Rating: 4.5 (1 reviews)

(Synonyms: UFO, Tyro7, JTK11, AXL receptor tyrosine kinase, ARK) Copy Product Info

Synonyms: UFO, Tyro7, JTK11, AXL receptor tyrosine kinase, ARK

Catalog No. TMPY-06478 Copy Product Info

AXL Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 72.11 kDa and the accession number is AAH32229.1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$68	7-10 days	7-10 days
10 µg	$108	7-10 days	7-10 days
20 µg	$178	7-10 days	7-10 days
50 µg	$359	7-10 days	7-10 days
100 µg	$696	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Information

Bioactivity

Bioactivity	1.Recombinant Human AXL Protein, mFc Tag (Cat#TMPY-06478) captured on CM5 chip via Anti-Mouse antibody can bind Recombinant Human GAS6 Protein, His Tag with an affinity constant of 4.277 nM as determined in an SPR assay (Biacore T200) (Routinely tested).2.Recombinant Human AXL Protein, mFc Tag (Cat#TMPY-06478) captured on CM5 via Anti-mouse antibody chip can bind Recombinant Human GAS6 Protein, His Tag with an affinity constant of 6.895 nM as determined in an SPR assay (Biacore T200) (Routinely tested).
Description	AXL Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 72.11 kDa and the accession number is AAH32229.1.
Species	Human
Expression System	HEK293 Cells
Tag	C-mFc
Accession Number	AAH32229.1
Construction	A DNA sequence encoding the human AXL (AAH32229.1) (Met1-Pro449) was expressed with the Fc region of mouse IgG1 at the C-terminus. Predicted N terminal: Ala 26
Protein Purity	> 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	UFO, Tyro7, JTK11, AXL receptor tyrosine kinase, ARK
Research Background	Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. Axl expression correlates with poor prognosis in several cancers. Axl mediates multiple oncogenic phenotypes and activation of these RTKs constitutes a mechanism of chemoresistance in a variety of solid tumors. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo.

Chemical Properties

Molecular Weight

72.11 kDa (predicted); 86.3 kDa (reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.