The specific activity of BIRC7 was determined to be 30 nmol /min/mg by AMP-Glo kinase assay.

Livin/BIRC7 Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is Q96CA5.

Human

Baculovirus-Insect Cells

Recombinant full length human BIRC7 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

>95% as determined by SDS-PAGE.

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

BIRC7, a new member of inhibitor of the apoptosis protein family, is expressed in fetal tissues and most solid tumors in humans. BIRC7/livin expression is a novel prognostic marker in adult acute leukemia. Livin/BIRC7 is a member of the inhibitors of apoptosis proteins family, which are involved in tumor development through the inhibition of caspases. Livin/BIRC7 is specifically over-expressed in ACC, suggesting that it might be involved in adrenocortical tumorigenesis and represent a new molecular marker of malignancy.