VISTA Protein, Cynomolgus, Recombinant (His)

Name: VISTA Protein, Cynomolgus, Recombinant (His)
Brand: TargetMol
SKU: TMPY-04584
Rating: 4.5 (1 reviews)

(Synonyms: V-set immunoregulatory receptor, C9H10orf54) Copy Product Info

Synonyms: V-set immunoregulatory receptor, C9H10orf54

Catalog No. TMPY-04584 Copy Product Info

VISTA Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19 kDa and the accession number is F7F6S6.

Pack Size	Price	USA Stock	Global Stock
5 µg	$76	7-10 days	7-10 days
10 µg	$118	7-10 days	7-10 days
20 µg	$197	7-10 days	7-10 days
50 µg	$398	7-10 days	7-10 days
100 µg	$677	7-10 days	7-10 days
200 µg	$1,130	7-10 days	7-10 days
500 µg	$2,700	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized Cynomolgus/Rhesus macaque B7-H5, His Tag at 1 μg/ml (100 μl/Well) on the plate. Dose response curve for Anti-B7-H5 Antibody, hFc Tag with the EC50 of 4.2 ng/ml determined by ELISA
Description	VISTA Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19 kDa and the accession number is F7F6S6.
Species	Cynomolgus
Expression System	HEK293 Cells
Tag	C-His
Accession Number	F7F6S6
Construction	Phe33-Thr192
Protein Purity	> 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Synonyms	V-set immunoregulatory receptor, C9H10orf54
Research Background	VSIR (V-Set Immunoregulatory Receptor, also known as VISTA) is a Protein Coding gene. VISTA is an immunoregulatory receptor that inhibits the T-cell response. It may promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. VSIR, or V-set immunoregulatory receptor, could be involved in the pathogenesis of chronic rhinosinusitis with nasal polyps. V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an inhibitory immune-checkpoint molecule that suppresses CD4+ and CD8+ T cell activation when expressed on antigen-presenting cells. VSIR is broadly expressed in the spleen, bone marrow, and other tissues. Diseases associated with VSIR include Ichthyosis, Congenital, Autosomal Recessive 6, and Monckeberg Arteriosclerosis. An important paralog of this gene is VSIG8.

Chemical Properties

Molecular Weight

19 kDa (predicted); 40-60 kDa (reducing conditon due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.