EphA7 Protein, Mouse, Recombinant (GST)

Catalog No. TMPC-00255 Copy Product Info

EphA7 Protein, Mouse, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is Q8R381.

EphA7 Protein, Mouse, Recombinant (GST)

Catalog No. TMPC-00255

Copy Product Info

EphA7 Protein, Mouse, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is Q8R381.

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10 μg	$1,390	Inquiry	Inquiry

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	The specific activity of EPHA7 was determined to be 35-44 nmol /min/mg by radioactive kinase assay.
Description	EphA7 Protein, Mouse, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is Q8R381.
Species	Mouse
Expression System	Baculovirus-Insect Cells
Tag	N-GST
Accession Number	Q8R381
Synonyms	Ephrin type-A receptor 7,Epha7,EPH homology kinase 3
Construction	Recombinant mouse EPHA7 (580-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Protein Purity	>95% as determined by SDS-PAGE.
Molecular Weight	~73 kDa
Formulation	Supplied as sterile 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Research Background	Ephrin type-A receptor 7, also known as EphA7, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Eph receptor-mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induces various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. Down-regulation of EphA7 secondary to hypermethylation has been reported in colorectal cancer. The expression of EphA7 was reduced in all tested gastric cancer cell lines; however, there is marked variability in expression among gastric carcinoma specimens. EphA7 may have roles in the pathogenesis and development of gastric carcinomas.