OX40/TNFRSF4 Protein, Rhesus, Recombinant (His)

Name: OX40/TNFRSF4 Protein, Rhesus, Recombinant (His)
Brand: TargetMol
SKU: TMPY-04723
Rating: 4.5 (1 reviews)

(Synonyms: tumor necrosis factor receptor superfamily, member 4) Copy Product Info

Synonyms: tumor necrosis factor receptor superfamily, member 4

Catalog No. TMPY-04723 Copy Product Info

OX40/TNFRSF4 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.7 kDa and the accession number is A0A5F7ZEC3.

Pack Size	Price	USA Stock	Global Stock
5 µg	$76	7-10 days	7-10 days
10 µg	$118	7-10 days	7-10 days
20 µg	$197	7-10 days	7-10 days
50 µg	$398	7-10 days	7-10 days
100 µg	$677	7-10 days	7-10 days
200 µg	$1,130	7-10 days	7-10 days
500 µg	$2,700	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	1.Immobilized Recombinant Rhesus OX40/TNFRSF4 Protein (His Tag) (Cat#TMPY-04723) at 1 μg/mL (100 μL/well) can bind Anti-OX40 (Vonlerolizumab Biosimilar), the EC50 is 2.8 ng/mL (Routinely tested). 2.Immobilized Recombinant Rhesus OX40/TNFRSF4 Protein (His Tag) (Cat#TMPY-04723) at 2 μg/mL (100 μL/well) can bind Recombinant Human OX40 Ligand/TNFSF4 Protein (hFc Tag) (Cat#TMPY-04832), the EC50 is 2-10 ng/mL (QC tested).
Description	OX40/TNFRSF4 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.7 kDa and the accession number is A0A5F7ZEC3.
Species	Rhesus
Expression System	HEK293 Cells
Tag	C-His
Accession Number	A0A5F7ZEC3
Construction	A DNA sequence encoding the rhesus TNFRSF4 (XP_001090870.1) (Met1-Ala216) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Leu 29
Protein Purity	> 95 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	tumor necrosis factor receptor superfamily, member 4
Research Background	OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

21.7 kDa (predicted); 42.4 kDa (reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.