BTK Protein, Rat, Recombinant (GST)

Catalog No. TMPC-00088 Copy Product Info

BTK Protein, Rat, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is A0A0G2K6M9.

BTK Protein, Rat, Recombinant (GST)

Catalog No. TMPC-00088

Copy Product Info

BTK Protein, Rat, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is A0A0G2K6M9.

Pack Size	Price	USA Stock	Global Stock	Quantity
10 μg	$1,390	35 days	35 days

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	The specific activity of BTK was determined to be 66 nmol /min/mg by radioactive kinase assay.
Description	BTK Protein, Rat, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is A0A0G2K6M9.
Species	Rat
Expression System	Baculovirus-Insect Cells
Tag	N-GST
Accession Number	A0A0G2K6M9
Synonyms	Tyrosine-protein kinase,btk
Construction	Recombinant full length rat BTK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Protein Purity	>95% as determined by SDS-PAGE.
Molecular Weight	~105 kDa
Formulation	Supplied as sterile 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Research Background	Bruton's tyrosine kinase (or BTK) is a type of kinase protein expressed in B lymphocytes and T cells. BTK contains a PH domain which binds phosphatidylinositol(3,4,5)-trisphosphate (PIP3). After binding to PIP3, BTK is induced to phosphorylate phospholipase C, which in turn hydrolyzes PIP2 into two second messagers, IP3 and DAG, which then modulate the activity of downstream proteins during B-cell signaling. Btk is also found implicated in the primary immunodeficiency disease X-linked agammaglobulinemia(Bruton's agammaglobulinemia). BTK played a key role in B-cell maturation as well as mast cell activation through the high-affinity IgE receptor. Patients with X-linked agammaglobulinemia have normal pre-B cell populations in their bone marrow but these B-cells can not mature and enter the circulation.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy