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Claudin-6 Protein, Human, Recombinant

Catalog No. TMPY-06586
Synonyms: claudin 6

Claudin-6 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 23.30 kDa and the accession number is NP_067018.2.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Claudin-6 Protein, Human, Recombinant
Pack Size Availability Price/USD Quantity
20 μg 5 days $ 838.00
100 μg 5 days $ 1,670.00
500 μg 5 days $ 5,310.00
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Biological Description
Technical Params
Product Properties
References and Literature
Description Claudin-6 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 23.30 kDa and the accession number is NP_067018.2.
Species Human
Expression System HEK293 Cells
Tag Tag Free
Accession Number NP_067018.2
Synonyms claudin 6
Construction Human CLDN6 (NP_067018.2) (Met1-Val220)
Molecular Weight 23.30 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Supplied as sterile solution in 50 mM HEPES, 150 mM NaCI, 10% Trehalose, pH 7.2.
Stability & Storage

It is recommended to store the product under sterile conditions at -70℃ or lower. Samples are stable for up to 12 months at -80℃. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

Research Background Claudin-6 (CLDN6) belongs to the claudins family and is a transmembrane protein found in tight junctions with two extracellular loops and intracellular N and C tails. CLDN6 modulates the ion- and charge-specific permeability of the paracellular pathway in most epithelial tissues. It regulates the paracellular flux of cations in the kidney through forming heterotypic strands with other claudins and has a role in maintaining the lung epithelial barrier function. The CLDN6 gene is adjacent to another family member, CLDN9, on chromosome 16. Certain CLDN6-positive cancers, encompassing ovarian, endometrial, and testicular malignancies, have been shown to have their proliferation and invasiveness suppressed upon CLDN6 silencing.

References and Literature

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Keywords

Claudin-6 Protein, Human, Recombinant claudin 6 recombinant recombinant-proteins proteins protein

 

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