Claudin-6 Protein, Human, Recombinant

Catalog No. TMPY-06586

Claudin-6 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 23.30 kDa and the accession number is NP_067018.2.

Claudin-6 Protein, Human, Recombinant

Catalog No. TMPY-06586

Claudin-6 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 23.30 kDa and the accession number is NP_067018.2.

Pack Size	Price	Availability
5 μg	$298	7-10 days
10 μg	$490	7-10 days
20 μg	$838	7-10 days
50 μg	$1,230	7-10 days
100 μg	$1,930	7-10 days
200 μg	$2,750	7-10 days
500 μg	$6,150	7-10 days

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Product Information

Biological Activity	Immobilized Human CLDN6-VLP (Full Length) Protein at 5 μg/mL (100 μL/well) can bind Anti-Human CLDN6 Antibody, Human IgG1, the EC50 is 2-10 ng/mL.
Description	Claudin-6 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 23.30 kDa and the accession number is NP_067018.2.
Species	Human
Expression System	HEK293 Cells
Tag	Tag Free
Accession Number	NP_067018.2
Synonyms	claudin 6
Construction	A DNA sequence encoding the human CLDN6 (NP_067018.2) (Met1-Val220) was expressed. Predicted N terminal: Met 1
Molecular Weight	23.30 kDa (predicted)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as sterile solution in 50 mM HEPES, 150 mM NaCI, 10% Trehalose, pH 7.2.
Stability & Storage	It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Shipping with blue ice.
Research Background	Claudin-6 (CLDN6) belongs to the claudins family and is a transmembrane protein found in tight junctions with two extracellular loops and intracellular N and C tails. CLDN6 modulates the ion- and charge-specific permeability of the paracellular pathway in most epithelial tissues. It regulates the paracellular flux of cations in the kidney through forming heterotypic strands with other claudins and has a role in maintaining the lung epithelial barrier function. The CLDN6 gene is adjacent to another family member, CLDN9, on chromosome 16. Certain CLDN6-positive cancers, encompassing ovarian, endometrial, and testicular malignancies, have been shown to have their proliferation and invasiveness suppressed upon CLDN6 silencing.