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Cat No. | Product Name | Synonyms | Targets |
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T5831 | Selective PI3Kδ Inhibitor 1 | PI3K | |
Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM). | |||
T80930 | TRPV2-selective blocker 1 | ||
TRPV2-selective blocker 1 (compound IV2-1) is a selective inhibitor of the TRPV2 channel, exhibiting an IC50 value of 6.3 μM. It specifically targets the TRPV2 channel without impacting related TRPV1, TRPV3, or TRPV4 cha... | |||
T79184 | FKBP51F67V-selective antagonist Ligand2 | FKBP | |
FKBP51F67V-selective antagonist Ligand2 (example 3-3), a potent ligand, selectively binds to the FKBP51 F67V variant, with no affinity for wild-type FKBP51 or FKBP52 [1]. It effectively reverses the anxiogenic phenotype ... | |||
T16129 | MPI_5a | HDAC | |
MPI_5a is an effective and selective inhibitor of HDAC6 (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms and it also inhibits acyl-tubulin accumulation in cells (IC50: 210 nM). | |||
T19777 | ODQ | Apoptosis , Others , Guanylate cyclase | |
ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor. | |||
T19891 | Metolachlor | Others | |
Metolachlor is an organic compound. Metolachlor is also widely used as an herbicide. | |||
T8513 | Spastazoline | Others | |
Spastazoline is a potent and selective inhibitor of spastin(Human spastin with IC50 of 99 nM ). | |||
T8485 | THIQ | Melanocortin Receptor | |
THIQ is a selective melanocortin-4 receptor (MC4R) agonist (hMC4R and rMC4R with IC50 of 1.2 nM and 0.6 nM , respectively). | |||
T8580 | Bupranolol | Adrenergic Receptor | |
Bupranolol is an antagonist of β2-adrenergic receptor and has been used for angina pectoris, hypertension, glaucoma, cardiac arrhythmia and as an antithrombotic. | |||
T2430 | HPOB | Apoptosis , HDAC | |
HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs. | |||
T9925 | Ofatumumab | Others | |
Ofatumumab is a fully human monoclonal antibody to CD20 which appears to inhibit early-stage B lymphocyte activation | |||
T15729 | LDN-91946 | DUB | |
LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM). | |||
T9570 | Enpatoran | TLR | |
Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo. | |||
T22518 | 5-BDBD | P2X Receptor | |
5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal and acute hyperalgesia induced by NTG. | |||
T9118 | KEA1-97 | Apoptosis , Others , Caspase | |
Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M). Kea1-97 destroys the interaction between thioredoxin and caspase 3 and activates caspases without affecting the activity ... | |||
T3624 | A-366 | A 366,A366 | Epigenetic Reader Domain , Histone Methyltransferase |
A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1,000-fold selective for G9a and GLP over the other 21 met... | |||
T9452 | PW0787 | GPR | |
PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist (EC50=135 nM). | |||
T22341 | GSK-114 | Others | |
GSK-114, a selective inhibitor of TNNI3 Interacting Kinase (TNNI3K) with IC50 of 25 nM, shows significant bias for TNNI3K over B-Raf with IC50 of 1000 nM, exceptional broad spectrum kinase selectivity and adequate oral e... | |||
T8535 | GAK inhibitor 49 | Serine/threonin kinase | |
GAK inhibitor 49 is a highly selective and ATP-competitive cyclin G associated kinase (GAK) inhibitor (IC50: 56 nM; Ki: 0.54 nM ). | |||
T16745 | Rhosin hydrochloride | Apoptosis , Rho , Ras | |
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 o... | |||
T7538 | Tetraethylammonium chloride | Potassium Channel | |
Tetraethylammonium chloride is a quaternary ammonium compound. It is a non-selective potassium channel blocker. It is a good substrate for organic cation transporter proteins and has antitumor properties. | |||
T7659 | Bisindolylmaleimide IV | Others , PKC | |
Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 μM) | |||
T2293 | SGX-523 | Raf , p38 MAPK , c-Met/HGFR , Bcr-Abl | |
SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf. | |||
T9215 | ELOVL6-IN-2 | Others | |
ELOVL6-IN-2 is a orally active and selective ELOVL6 inhibitor. | |||
T2164 | Wiskostatin | Others | |
Wiskostatin is a selective inhibitor of N-WASP, a ubiquitously expressed member of the Wiskott-Aldrich Syndrome protein (WASp) family that regulates actin polymerization. | |||
T9214 | ELOVL6-IN-1 | Others | |
ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner... | |||
T7149 | S29434 | NADPH , Autophagy | |
S29434 (NMDPEF) is a potent, competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM). | |||
T11014 | DFP00173 | Aquaporin | |
DFP00173 is a potent and selective aquaporin 3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with IC50 of ~0.1-0.4 μM. Compared with the homologous AQP subtypes AQP7 and AQP9, DFP00173 is selective for AQP3. | |||
T9194 | UMB298 | Epigenetic Reader Domain | |
UMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM. | |||
T8418 | DCLK1-IN-1 | Others | |
DCLK1-IN-1 is a selective and in vivo-compatible chemical probe of the DCLK1 kinase domain . | |||
T11689 | ITI-214 | ITI214 | PDE |
ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = ... | |||
T22748 | DQP 1105 | NMDAR | |
DQP 1105 is a NMDA receptor antagonist. | |||
T38163 | ML-148 | Dehydrogenase | |
ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM). ML-148 can be used to profile across a panel of related dehydrogenase or reductase enzymes and in studies about prostagla... | |||
TP1898 | HS024 | HS 024 | Melanocortin Receptor |
HS024 is a highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-... | |||
T9882 | RUVBL1/2 ATPase-IN-1 | Others | |
RUVBL1/2 ATPase-IN-1 is an effective RUVBL1/2 ATPase inhibitor with IC50 values of 6.0 and 7.7 μM, respectively. RUVBL1/2 ATPase-IN-1 can be used in cancer disease studies. | |||
T3474 | RO 46-8443 | Endothelin Receptor | |
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. | |||
T9164 | BMS-986242 | BMS986242 | IDO , Indoleamine 2,3-Dioxygenase (IDO) |
BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer. | |||
T4534 | BMS-309403 | FABP | |
BMS-309403 is an effective, selective and cell-permeable inhibitor of fatty acid binding protein 4 (FABP4) with a Ki of less than 2 nM. | |||
T7414 | ARS-853 | Apoptosis , Raf , Ras | |
ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells | |||
T4378 | MS049 | Histone Methyltransferase | |
MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively. | |||
T11723L | JNJ-39758979 | Histamine Receptor | |
JNJ-39758979 is a selective and high-affinity histamine H4 receptor antagonist (Kis: 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively). JNJ-39758979 functionally antagonizes histamine... | |||
T3072 | XL019 | Apoptosis , FLT , JAK , PDGFR | |
XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1. | |||
T5436 | MZ 1 | Epigenetic Reader Domain | |
MZ 1 is a BRD4 protein degrader based on PROTAC technology. | |||
T8450 | TCN 213 | TCN213 | NMDAR |
TCN 213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B | |||
T16143 | MRTX-1257 | Ras | |
MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C. It has an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. MRTX1257 demonstrated 31% bioavailability in the mouse, with fre... | |||
T22514 | 4F 4PP oxalate | 5-HT Receptor | |
4F 4PP oxalate is a 5-HT2A antagonist. | |||
T3284 | Carazolol | Conducton,Suacron | Adrenergic Receptor |
Carazolol (Suacron) is a high-affinity antagonist/partial inverse agonist (also referred to as a beta blocker) of the β-adrenergic receptor. | |||
T15784 | LP99 | Epigenetic Reader Domain | |
LP99 is an epigenetic probe. LP99 disrupts the binding of BRD7 and BRD9 to chromatin in cells. LP99 is an effective and selective inhibitor of the BRD7 and BRD9 bromodomains (Kd: 99 nM against BRD9). | |||
T6977 | SB-366791 | SB366791 | TRP/TRPV Channel |
SB-366791 is a new and selective cinnamide TRPV1 antagonist. | |||
T15032 | CYM50308 | S1P Receptor , LPL Receptor | |
CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM and it shows 37-fold more sel... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1120 | Osthenol | MAO , Monoamine Oxidase | |
Osthenol is a natural product, and is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM).It shows antitumor-promoting activity, it also has antifungal and antibacterial activ... | |||
T9933 | Methyl 2,4-dihydroxyphenylacetate | Others | |
Methyl 2,4-dihydroxyphenylacetate is a natural product isolated from Nigella damascena seeds with selective phytotoxic effects. | |||
T5722 | Nevadensin | Pedunculin | Anti-infection , Antibacterial |
Nevadensin is an important herb-based constituent inhibiting estragole bioactivation. Nevadensin protects against a methyleugenol-induced marker of hepatocarcinogenicity in male F344 rat. It also exhibits inhibition acti... | |||
T15686 | L-741626 | 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole | Dopamine Receptor |
L-741626 (3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole) is a selective antagonist of D2 dopamine receptor (Ki: 2.4, 100, and 220 nM for human D2, D3 and D4 receptors respectively). | |||
TN1731 | Hernandezine | TNF , ROS , P-gp , AMPK | |
Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells. | |||
TQ0203 | Tafluprost | MK2452,AFP-168 | Prostaglandin Receptor |
Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2α. | |||
T2266 | SantacruzaMate A | CAY-10683 | HDAC |
SantacruzaMate A (CAY-10683) is a potent and selective HDAC inhibitor. | |||
T8035 | 3'-Methoxyflavonol | NMU2R | |
3'-Methoxyflavonol is a potent, selective agonist of neuromedin U 2 receptor (NMU2R). | |||
T23306 | Salvinorin A | Opioid Receptor | |
Salvinorin A is a non-nitrogenous κ-opioid selective agonist. | |||
T5838 | L-Canavanine sulfate | NO Synthase , NOD | |
L-Canavanine sulfate is a selective inducible NO synthase inhibitor. | |||
Fr12415 | Ethyl 4-hydroxyphenylacetate | Others | |
Ethyl 4-hydroxyphenylacetate is a selective inhibitor of monoamine oxidase A. | |||
TN4171 | Grossamide | NO Synthase | |
Grossamide (GSE) Grossamide is a lignan amide derived from thioguanosine.6-Thioguanosine (GSE) is a selective and potent miR-210 (miRNA-210) inhibitor.6-Thioguanosine (GSE) is a selective and potent miR-210 (miRNA-210) i... | |||
T13475 | β-Aminopropionitrile | 3-Aminopropionitrile,BAPN | Others , Endogenous Metabolite |
β-Aminopropionitrile (3-Aminopropionitrile) is a selective inhibitor of lysyl oxidase. | |||
TMA1122 | N-Feruloylserotonin | (E/Z)-Moschamine,Moschamine | Antioxidant |
N-Feruloylserotonin ((E/Z)-Moschamine) is a selective FAAH inhibitor that inhibits [H]-AEA uptake and cell proliferation at low concentrations. | |||
T6995 | Ochromycinone | STA 21,STA21,STA-21 | Antibacterial , STAT |
Ochromycinone (STA 21) is a selective STAT3 inhibitor. | |||
TN2202 | Sempervirine | DNA/RNA Synthesis | |
Sempervirine can unwind circular DNA, it shows selective inhibition of in vitro synthesis of cancer DNA . | |||
T8299 | Dimethyl lithospermate B | dmLSB | Sodium Channel |
Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. | |||
T3432 | Cinobufagin | Cinobufagine | Apoptosis , ATPase , Autophagy |
Cinobufagin (Cinobufagine) is a selective Na+/K+-ATPase inhibitor. The activity of Cinobufagin is same as ouabain. | |||
T1680 | Tolazoline hydrochloride | Imidaline hydrochloride,Imidaline (hydrochloride),Benzidazol hydrochloride,Tolazoline HCl,NSC35110 (hydrochloride) | Adrenergic Receptor |
Tolazoline hydrochloride (NSC35110 (hydrochloride)) is a non-selective competitive α-adrenergic receptor antagonist used in treatment of persistent pulmonary hypertension of the newborn. | |||
T0453 | Phenylephrine hydrochloride | NCI-c55641,Phenylephrine HCl,(R)-(-)-Phenylephrine hydrochloride | Endogenous Metabolite , Adrenergic Receptor |
Phenylephrine hydrochloride (NCI-c55641) is a selective agonist of the α1-adrenergic receptor. | |||
T4643 | TFAP | N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide | COX , Endogenous Metabolite |
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) is a selective cyclooxygenase-1 (COX-1) inhibitor | |||
T4S1521 | 1,4-Dicaffeoylquinic acid | HIV Protease | |
1,4-Dicaffeoylquinic acid has antioxidant activity.1,4-Dicaffeoylquinic acid is a potent and highly selective class of HIV-1 integrase inhibitors, inhibitsHIV-1 replication in MT-2 cell culture at non-toxic concentration... | |||
T8187 | Tetrahydroepiberberine | Others , Influenza Virus , Antifungal | |
Tetrahydroepiberberine, an isoquinoline alkaloid, has antifungal and selective inhibition against the PI-3 virus activities. | |||
T8125 | Quinidine sulfate dihydrate | Chinidin Sodium,β-quinine Sodium,Pitayine Sodium,Quinidine sulfate | P450 |
Quinidine sulfate dihydrate (Pitayine Sodium) is a potent and selective cytochrome P450db inhibitor | |||
T17310 | Phenylephrine | L-Phenylephrine,(R)-(-)-Phenylephrine | Adrenergic Receptor |
Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively). | |||
TQ0196 | Cucurbitacin I | NSC-521777,JSI-124,Elatericin B | JAK , STAT |
Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity. | |||
T5743 | Gymnemagenin | Liver X Receptor | |
Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity. | |||
TN4618 | N-trans-Sinapoyltyramine | Others | |
N-trans-Sinapoyltyramine exhibited strong and selective cytotoxicity on the HeLa human cancer cell line with IC50 values of 9.77 ± 1.25 Μm. | |||
TN1817 | Kaempferol 3,7,4'-trimethyl ether | Kaempferol 3,7,4'-trimethylether | NO Synthase |
Kaempferol 3,7,4'-trimethyl ether (Kaempferol 3,7,4'-trimethylether) shows selective cyctoxic activities against the nine tested cancer cell lines. | |||
TQ0274 | 27-Hydroxycholesterol | 25(R)-27-hydroxy Cholesterol | Estrogen/progestogen Receptor , Liver X Receptor |
27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor. | |||
T1186 | Ifenprodil Tartrate | Potassium Channel , NMDAR , iGluR | |
Ifenprodil is a selective NMDA receptor (glutamate) antagonist. | |||
TN1490 | Chrysoeriol | ERK , p38 MAPK , Akt | |
Chrysoeriol has antioxidant, antiinflammatory, antitumor, antimicrobial, antiviral, and free radical scavenging activities, it also shows selective bronchodilator effect. | |||
T2922 | Phlorizin | Floridzin,NSC 2833,Phloridzin | ATPase , SGLT |
Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) . | |||
T21581L | AC 187 Acetate | AC 187 Acetate (151804-77-2 Free base) | Amylin Receptor |
AC 187 Acetate is a potent antagonist of amylin receptor .AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors. | |||
T7607 | PSI-6130 | R 1656 | HCV Protease |
PSI-6130 (R 1656) is a potent and selective HCV NS5B polymerase inhibitor. PSI-6130 inhibits HCV replication with a mean IC50 of 0.6 μM. | |||
TN2107 | Protoescigenin | Others | |
Protoescigenin is from horse chestnut saponin mixture and can be used as the substrate for exploratory chemistry towards selective protection. | |||
T13469 | (±)-Huperzine A | AChE | |
(±)-Huperzine A is an active Lycopodium alkaloid extracted from traditional Chinese herbs. (±)-Huperzine A is a selective and reversible inhibitor of AChE and can be used in studies about the treatment of Alzheimer's dis... | |||
T0505 | Methyldopa | L-(-)-α-Methyldopa,MK-351 | Dopamine Receptor , Adrenergic Receptor |
Methyldopa (MK-351), an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive medicine, is served as an antihypertensive or sympatholytic. | |||
T6841 | Fumagillin | NSC9168,Amebacilin | Others , HIV Protease , Antibiotic , Parasite |
Fumagillin (Amebacilin) is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis. | |||
T6648 | Rotundine | Gindarine,L-Tetrahydropalmatine,Caseanine,(-)-Tetrahydropalmatine | Dopamine Receptor , 5-HT Receptor |
Rotundine (Gindarine) (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM. | |||
TQ0288 | Hexahydrocurcumin | Reactive Oxygen Species , ROS , COX | |
Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1. | |||
T3325 | Liquiritigenin | 4',7-Dihydroxyflavanone | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Liquiritigenin (4',7-Dihydroxyflavanone), a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist. | |||
T17048 | Tetradecanoylcarnitine | L-Myristoylcarnitine,Myristoyl-L-(-)-carnitine | Endogenous Metabolite |
Tetradecanoylcarnitine (L-Myristoylcarnitine) is an acylcarnitine involved in the beta-oxidation of long-chain fatty acids, and is a potential marker for very-long-chain coenzyme A dehydrogenase deficiency. alpha-Dihydro... | |||
T8895 | Altenusin | FXR | |
Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM. | |||
TN6739 | Angoline | 6-Methoxyldihydrochelerythrine | IL Receptor , STAT |
Angoline (6-Methoxyldihydrochelerythrine) hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits can... | |||
TN2252 | Syrosingopine | Dopamine Receptor | |
Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor. | |||
T1125 | Shikonin | NSC 252844,Isoarnebin 4,(+)-Shikonin,Alkanna Red,C.I. 75535,Anchusa acid | TNF , NF-κB , Chloride channel , HIV Protease , PKM |
Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and selective PKM2 inhibitor. Shikonin exhibits antitumor, anti-inflammatory and wound healing activities. | |||
T0167 | Vinpocetine | RGH-4405,Ethyl apovincaminate | IκB/IKK , NF-κB , Sodium Channel , PDE |
Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE). | |||
T0906 | Salinomycin | Procoxacin | Wnt/beta-catenin , Antibacterial |
Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, specifically inhibits the growth of gram-positive bacteria. It acts as a potent inhibitor of Wnt/β-catenin signaling, blocking Wnt-induced LRP6 phosph... | |||
T8114 | Quercetagetin | 6-Hydroxyquercetin | Pim |
Quercetagetin (6-Hydroxyquercetin) (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu. It is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50: 0.34 μM). | |||
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Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01068 | FKBP25/FKBP3 Protein, Human, Recombinant (His) | Human | E. coli |
FKBP25 contains 1 PPIase FKBP-type domain, belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell prolif... | |||
TMPY-02292 | IGSF11 Protein, Human, Recombinant (His) | Human | HEK293 |
Immunoglobulin superfamily member 11(IGSF11) is expressed on the plasma membrane in the testis and brain. These IGSF proteins undergo final modifications during capacitation and/or the acrosome reaction. IGSF proteins sh... | |||
TMPY-02626 | FGF-18 Protein, Human, Recombinant (His) | Human | HEK293 |
Fibroblast growth factor 18 (FGF18) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes... | |||
TMPY-01460 | ABHD4 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Abhydrolase domain containing 4 (ABHD4), also known as alpha/beta-hydrolase 4 (ABH4) , or lyso-N-acylphosphatidylethanolamine lipase, which belongs to the ABHD4/ABHD5 subfamily of peptidase S33 family. Abhydrolase domain... | |||
TMPY-02566 | Interferon alpha 4/IFNA4 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Interferon, alpha 4 (IFNA4) belongs to the alpha/beta interferon family. Two variants of IFNA4 (IFNA4a and IFNA4b) are known, which differ from each other by changes in their coding regions at nucleotide positions 220 an... | |||
TMPY-01371 | IL-17RA Protein, Human, Recombinant (His) | Human | HEK293 |
Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor that binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secret... | |||
TMPY-01068 | CD70 Protein, Human, Recombinant (hFc) | Human | HEK293 |
CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor, CD27, is important in priming, effector functions, diff... | |||
TMPY-01081 | SR-BI/SCARB1 Protein, Human, Recombinant (His) | Human | HEK293 |
Scavenger receptor class B, member 1 (SCARB1), also known as CD36L1, is a member of the scavenger receptor family. SCARB1 is expressed primarily in liver and non placental steroidogenic tissues, and predominantly localiz... | |||
TMPY-05365 | BAFF/TNFSF13B Protein, Human, Recombinant (Avi & Fc), Biotinylated | Human | HEK293 |
B lymphocyte stimulator (BLyS), also known as TNFSF13B, CD257 and BAFF, is a single-pass type II membrane protein, which belongs to the tumor necrosis factor family. BAFF is abundantly expressed in peripheral blood Leuko... | |||
TMPY-01920 | BAFF/TNFSF13B Protein, Human, Recombinant (HEK293) | Human | HEK293 |
B lymphocyte stimulator (BLyS), also known as TNFSF13B, CD257 and BAFF, is a single-pass type II membrane protein, which belongs to the tumor necrosis factor family. BAFF is abundantly expressed in peripheral blood Leuko... | |||
TMPY-03645 | BAFF/TNFSF13B Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 |
B lymphocyte stimulator (BLyS), also known as TNFSF13B, CD257 and BAFF, is a single-pass type II membrane protein, which belongs to the tumor necrosis factor family. BAFF is abundantly expressed in peripheral blood Leuko... | |||
TMPY-01356 | S100A8 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
S100A8 is a member of the S100 protein family containing 2EF-hand calcium-binding motifs. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation.... | |||
TMPY-00834 | IGF1R/CD221 Protein, Human, Recombinant (His) | Human | HEK293 |
The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide... | |||
TMPH-03043 | PIA Protein, MenB, Recombinant (His) | MenB | E. coli |
Serves as a slightly cation selective porin. Major antigen on the gonococcal cell surface and it may have pathogenic properties in addition to its porin activity. | |||
TMPH-03174 | LecA Protein, Pseudomonas aeruginosa, Recombinant (His) | Pseudomonas aeruginosa | E. coli |
D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carb... | |||
TMPH-00379 | MLCK Protein, Chicken, Recombinant (His & Myc & SUMO) | Chicken | E. coli |
Phosphorylates a specific serine in the N-terminus of a myosin light chain, which leads to the formation of calmodulin/MLCK signal transduction complexes which allow selective transduction of calcium signals. | |||
TMPH-01816 | OX1R Protein, Human, Recombinant (His & SUMOstar) | Human | Yeast |
Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. | |||
TMPK-00394 | FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in num... | |||
TMPK-00392 | FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in num... | |||
TMPY-04904 | Zika virus (ZIKV) (strain Zika SPH2015) M/Membrane protein (Fc) | ZIKV | HEK293 |
Zika virus (ZIKV) infection causes microcephaly and has been linked to other brain abnormalities. ZIKV has a more selective and larger impact on the expression of genes involved in DNA replication and repair. P53 inhibit... | |||
TMPH-01684 | MAP1LC3C Protein, Human, Recombinant (His) | Human | E. coli |
Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium. May also p... | |||
TMPH-01693 | MAP3K14 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-ka... | |||
TMPH-02905 | TRPC1 Protein, Mouse, Recombinant (His) | Mouse | in vitro E. coli expression system |
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled recep... | |||
TMPJ-01221 | UBE2J2 Protein, Human, Recombinant (GST) | Human | E. coli |
Ubiquitin-Conjugating Enzyme E2 J2 (UBE2J2) belongs to the ubiquitin-conjugating enzyme family. UBE2J2 is involved in the ubiquitiantion. UBE2J2 located in the membrane of the endoplasmic reticulum, catalyzes the covalen... | |||
TMPH-00340 | ATG1 Protein, Candida glabrata, Recombinant (His) | Candida glabrata | E. coli |
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein ... | |||
TMPJ-00273 | IGSF11 Protein, Human, Recombinant (hFc) | Human | Human Cells |
Immunoglobulin superfamily member 11(IGSF11) is abundantly expressed in testis and ovary and to a lower extent in brain, kidney and skeletal muscle.IGSF11 functions as a cell adhesion molecule through homophilic interact... | |||
TMPK-00564 | TNFR1/CD120a/TNFRSF1A Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of... | |||
TMPK-00171 | TRAIL Trimer Protein, Human, Recombinant (His & Flag) | Human | HEK293 |
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can initiate the apoptosis pathway by binding to its associated death receptors DR4 and DR5. The activation of... | |||
TMPH-02263 | VASH1 Protein, Human, Recombinant (His) | Human | E. coli |
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mito... | |||
TMPH-02118 | SCN1A Protein, Human, Recombinant (His) | Human | E. coli |
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective chann... | |||
TMPH-02986 | Murine polyomavirus (MPyV) (strain Kilham) VP2 Protein (His) | MPyV | E. coli |
Isoform VP2 is a structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers. Participates in host cell receptor binding together with VP1. Following virus endocytosis and trafficking to ... | |||
TMPJ-01363 | CLIC5 Protein, Human, Recombinant (His) | Human | E. coli |
Chloride Intracellular Channel Protein 5 (CLIC5) is a single-pass membrane protein which belongs to the chloride channel CLIC family. It contains one GST C-terminal domain. Chloride intracellular channels are involved in... | |||
TMPY-05003 | GLTP Protein, Human, Recombinant (His) | Human | HEK293 |
Glycolipid transfer proteins (GLTPs) originally were identified as small (~24 kDa), soluble, amphitropic proteins that specifically accelerate the intermembrane transfer of glycolipids. Human GLTP-motifs have evolved to ... | |||
TMPJ-00891 | Kallikrein 2/KLK2 Protein, Human, Recombinant (His) | Human | Human Cells |
Kallikrein-2 (KLK2) is a secreted serine protease that belongs to the peptidase S1 family of Kallikrein subfamily. KLK2 contains 1 peptidase S1 domain. It is highly expressed in the human prostate gland. KLK2 can cleave ... | |||
TMPH-00026 | Catechol 1,2-dioxygenase Protein, Acinetobacter baylyi, Recombinant (His) | Actinia equina | E. coli |
Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphin... | |||
TMPJ-01039 | UBE2K Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain, with highest levels found in cortex and striatum, and at lower levels in cerebellum... | |||
TMPH-02531 | ARID5A Protein, Mouse, Recombinant (His) | Mouse | Yeast |
DNA-binding protein that may regulate transcription and act as a repressor by binding to AT-rich stretches in the promoter region of target genes. May positively regulate chondrocyte-specific transcription such as of COL... | |||
TMPJ-01038 | UBE2K Protein, Human, Recombinant (GST) | Human | E. coli |
Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain, with highest levels found in cortex and striatum, and at lower levels in cerebellum... | |||
TMPH-02301 | VPS35 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transm... | |||
TMPY-06798 | Claudin-9 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Claudin-9 (CLDN9) belongs to the claudins family and is a transmembrane protein found in tight junctions with two extracellular loops and a cytoplasmic C tail. CLDN9 modulates the ion- and charge-specific permeability o... | |||
TMPY-06902 | Claudin-9 Protein, Human, Recombinant | Human | HEK293 |
Claudin-9 (CLDN9) belongs to the claudins family and is a transmembrane protein found in tight junctions with two extracellular loops and a cytoplasmic C tail. CLDN9 modulates the ion- and charge-specific permeability o... | |||
TMPH-02365 | JC polyomavirus (JCV) Minor capsid protein VP2 (His) | JCPyV | E. coli |
Isoform VP2 is a structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers. Participates in host cell receptor binding together with VP1. Following virus endocytosis and trafficking to ... | |||
TMPH-00715 | Mcr-1 Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli |
Probably catalyzes the addition of a phosphoethanolamine moiety to lipid A. Phosphoethanolamine modification of lipid A gives polymyxin resistance.; Confers resistance to polymyxin-type antibiotics; expression of the Mcr... | |||
TMPH-02803 | NRROS Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifi... | |||
TMPH-02231 | NRROS Protein, Human, Recombinant (E. coli, His & Myc) | Human | E. coli |
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifi... | |||
TMPH-02347 | Influenza A H1N1 (strain A/USA:Phila/1935) Matrix protein 2 (His) | H1N1 | E. coli |
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of th... | |||
TMPH-02230 | NRROS Protein, Human, Recombinant (His & Myc) | Human | Baculovirus |
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifi... | |||
TMPY-01812 | Enoyl-ACP Reductase Protein, E. coli, Recombinant (His) | E. coli | E. coli |
Enoyl-ACP reductase, also known as NADH-dependent enoyl-ACP reductase and FABI, is a cell inner membrane and peripheral membrane protein which belongs to theshort-chain dehydrogenases/reductases (SDR) family and FabI ... | |||
TMPH-02348 | Influenza A H1N1 (strain A/Puerto Rico/8/1934) Matrix protein 2 (His & Myc) | H1N1 | E. coli |
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of th... | |||
TMPH-02108 | SH3YL1 Protein, Human, Recombinant (His) | Human | E. coli |
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Cat No. | Product Name | ||
---|---|---|---|
L2010 | Highly Selective Inhibitor Library | 580 compounds | |
A collection of xunm highly selective inhibitors | |||
L7200 | Calcium Channel Compound Library | 143 compounds | |
A unique collection of 143 calcium channel blockers and agonists for high throughput and high content screening; | |||
L7400 | Sodium Channel Blocker Library | 128 compounds | |
A unique collection of 128 sodium channel blockers and agonists for high throughput and high content screening; | |||
L7300 | Potassium Channel Blocker Library | 160 compounds | |
A unique collection of 160 potassium channel blockers and agonists for high throughput and high content screening; | |||
L5900 | CNS-Penetrant Compound Library | 516 compounds | |
A unique collection of 516 CNS-Penetrant compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L2520 | Glycometabolism Compound Library | 708 compounds | |
708 glycometabolism-related comounds, can be used for HTS and HCT; | |||
L9410 | Covalent Inhibitor Library | 1949 compounds | |
A unique collection of 1949 covalent Inhibitors and other molecules with common warheads like chloroacetyl,2-Chloropropionyl,Acryloyl,sulfonyl fluoride, alkyne,acrylamide, ketocarbonyl,disulfide bond, etc. |