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LAS38096

Name: LAS38096
Brand: TargetMol
SKU: T27800
Price: 147 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27800Cas No. 851371-22-7

Alias LAS-38096, LAS 38096

LAS38096 is an A2B adenosine receptor antagonist (Ki : 17 nM) that is potent, selective and efficient .

LAS38096

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Purity: 99.95%

Catalog No. T27800Alias LAS-38096, LAS 38096Cas No. 851371-22-7

LAS38096 is an A2B adenosine receptor antagonist (Ki : 17 nM) that is potent, selective and efficient .

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$147	In Stock	In Stock
5 mg	$348	In Stock	In Stock
10 mg	$475	In Stock	In Stock
25 mg	$667	In Stock	In Stock
50 mg	$887	In Stock	In Stock
100 mg	$1,220	In Stock	In Stock
200 mg	$1,630	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.95%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

LAS38096 AI Summary

LAS38096 exhibits significant bioactivity and modulation properties related to adenosine receptors. It shows high affinity for the human A2B receptor with a Ki value of 17.0 nM and moderate affinity for mouse A2B receptors with IC50 values of 321.0 nM in HEK293 cells and 349.0 nM in CHO cells. Additionally, it inhibits the production of NECA-induced cAMP and displays inhibitory activity on IL6 production in human (IC50 = 340.0 nM) and mouse fibroblasts (IC50 = 640.0 nM). LAS38096 also targets other adenosine receptors, presenting moderate affinity for the A3 receptor (Ki = 1043.0 nM) and low affinity for the A1 receptor (Ki = 2821.0 nM), and inhibits binding to the A2A receptor by 40% at 1 µM concentration. It has shown inhibitory potentials across various kinases, with Ki values ranging from 1258.93 nM to 6309.57 nM. Additionally, it has a high level of plasma protein binding across species (mouse, human, and rat) with values ranging from 84.0% to 86.05%, indicating strong plasma protein affinity that could influence its pharmacokinetics..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	LAS38096 is an A2B adenosine receptor antagonist (Ki : 17 nM) that is potent, selective and efficient .
Targets&IC50	A2A:>2500 nM (Ki), A1:>1000 nM (Ki), A2B:17 nM (Ki), A3:>1000 nM (Ki)
Synonyms	LAS-38096, LAS 38096

Chemical Properties

Molecular Weight	316.32
Formula	C₁₇H₁₂N₆O
Cas No.	851371-22-7
Smiles	N(c1cccnc1)c1ncc(-c2ccncn2)c(n1)-c1ccco1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (173.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1614 mL	15.8068 mL	31.6136 mL	158.0678 mL
5 mM	0.6323 mL	3.1614 mL	6.3227 mL	31.6136 mL
10 mM	0.3161 mL	1.5807 mL	3.1614 mL	15.8068 mL
20 mM	0.1581 mL	0.7903 mL	1.5807 mL	7.9034 mL
50 mM	0.0632 mL	0.3161 mL	0.6323 mL	3.1614 mL
100 mM	0.0316 mL	0.1581 mL	0.3161 mL	1.5807 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc