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RA-839

Name: RA-839
Brand: TargetMol
SKU: T28497
Price: 133 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28497Cas No. 1832713-02-6

Alias RA839, RA 839

RA-839 is a potent small molecule Keap1 conjugate and selective Nrf2 signalling activator, as well as an inhibitor of Keap1/Nrf2 interaction with anticancer activity.RA-839 inhibits the expression of inducible nitric oxide synthase and inhibits nitric oxide release.

RA-839

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Purity: 98.38%

Catalog No. T28497Alias RA839, RA 839Cas No. 1832713-02-6

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$133	In Stock	In Stock
10 mg	$195	In Stock	In Stock
25 mg	$325	In Stock	In Stock
50 mg	$483	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.38%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

RA-839 AI Summary

RA-839 exhibits significant bioactivity in modulating the Keap1-Nrf2 protein-protein interaction, demonstrating binding affinity to both mouse and human KEAP1 Kelch domains. Expressed in Escherichia coli BL21, it shows a dissociation constant (Kd) of 6000.0 nM as measured by the VP-ITC assay. The compound also inhibits the interaction between human Keap1 Kelch domain and Nrf2-ETGE peptide with an IC50 value of 140.0 nM in the fluorescence polarization assay, and effectively displaces FITC-LDEETGEFL-NH2 from the domain. Additionally, it has a Ki of 48.0 nM for inhibiting the binding of Cys5-LDEETGEFL-NH2, an EC50 of 13000.0 nM for thermal stabilization, and a Kd of 470.0 nM by surface plasmon resonance analysis. These results suggest RA-839's potential in influencing the Nrf2 pathway, contributing to oxidative stress response mechanisms..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	RA-839 is a potent small molecule Keap1 conjugate and selective Nrf2 signalling activator, as well as an inhibitor of Keap1/Nrf2 interaction with anticancer activity.RA-839 inhibits the expression of inducible nitric oxide synthase and inhibits nitric oxide release.
Synonyms	RA839, RA 839

Chemical Properties

Molecular Weight	452.57
Formula	C₂₅H₂₈N₂O₄S
Cas No.	1832713-02-6
Smiles	Cc1cc(C)c(C)c(c1C)S(=O)(=O)Nc1ccc(N2CC[C@@H](C2)C(O)=O)c2ccccc12
Relative Density.	1.313 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (176.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2096 mL	11.0480 mL	22.0960 mL	110.4801 mL
5 mM	0.4419 mL	2.2096 mL	4.4192 mL	22.0960 mL
10 mM	0.2210 mL	1.1048 mL	2.2096 mL	11.0480 mL
20 mM	0.1105 mL	0.5524 mL	1.1048 mL	5.5240 mL
50 mM	0.0442 mL	0.2210 mL	0.4419 mL	2.2096 mL
100 mM	0.0221 mL	0.1105 mL	0.2210 mL	1.1048 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc