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RA-839

🥰Excellent
Catalog No. T28497Cas No. 1832713-02-6
Alias RA839, RA 839

RA-839 is a potent small molecule Keap1 conjugate and selective Nrf2 signalling activator, as well as an inhibitor of Keap1/Nrf2 interaction with anticancer activity.RA-839 inhibits the expression of inducible nitric oxide synthase and inhibits nitric oxide release.

RA-839

RA-839

🥰Excellent
Purity: 98.38%
Catalog No. T28497Alias RA839, RA 839Cas No. 1832713-02-6
RA-839 is a potent small molecule Keap1 conjugate and selective Nrf2 signalling activator, as well as an inhibitor of Keap1/Nrf2 interaction with anticancer activity.RA-839 inhibits the expression of inducible nitric oxide synthase and inhibits nitric oxide release.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$133In StockIn Stock
10 mg$195In StockIn Stock
25 mg$325In StockIn Stock
50 mg$483In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:98.38%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
RA-839 is a potent small molecule Keap1 conjugate and selective Nrf2 signalling activator, as well as an inhibitor of Keap1/Nrf2 interaction with anticancer activity.RA-839 inhibits the expression of inducible nitric oxide synthase and inhibits nitric oxide release.
SynonymsRA839, RA 839
Chemical Properties
Molecular Weight452.57
FormulaC25H28N2O4S
Cas No.1832713-02-6
SmilesCc1cc(C)c(C)c(c1C)S(=O)(=O)Nc1ccc(N2CC[C@@H](C2)C(O)=O)c2ccccc12
Relative Density.1.313 g/cm3 (Predicted)
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (176.77 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2096 mL11.0480 mL22.0960 mL110.4801 mL
5 mM0.4419 mL2.2096 mL4.4192 mL22.0960 mL
10 mM0.2210 mL1.1048 mL2.2096 mL11.0480 mL
20 mM0.1105 mL0.5524 mL1.1048 mL5.5240 mL
50 mM0.0442 mL0.2210 mL0.4419 mL2.2096 mL
100 mM0.0221 mL0.1105 mL0.2210 mL1.1048 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RA-839KEAP1-Nrf2
Related Tags: buy RA-839 | purchase RA-839 | RA-839 cost | order RA-839 | RA-839 chemical structure | RA-839 formula | RA-839 molecular weight
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