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Tianeptine sodium salt

Name: Tianeptine sodium salt
Brand: TargetMol
SKU: T2402
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2402Cas No. 30123-17-2

Alias Tianeptine sodium

Tianeptine sodium salt, a selective serotonin reuptake enhancer (SSRE), is used to treat major depressive episodes.

Tianeptine sodium salt

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😃Good

Purity: 99.82%

Catalog No. T2402Alias Tianeptine sodiumCas No. 30123-17-2

Tianeptine sodium salt, a selective serotonin reuptake enhancer (SSRE), is used to treat major depressive episodes.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$33	In Stock	In Stock
25 mg	$50	In Stock	In Stock
50 mg	$62	-	In Stock
100 mg	$92	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.82%

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Tianeptine sodium salt, a selective serotonin reuptake enhancer (SSRE), is used to treat major depressive episodes.
In vitro	Tianeptine attenuates behavioral symptoms induced by peripheral, but not central, administration of LPS or IL-1β in rats. It normalizes the scaling ratio of NMDA receptor-mediated to AMPA/kainate receptor-mediated current amplitudes and prevents the stress-induced reduction in NMDA-EPSC inactivation. Tianeptine treatment prevents the increase in corticotropin-releasing factor (CRF) mRNA levels in the dBNST triggered by CMS and reduces CRF mRNA levels in the dBNST of non-stressed rats. In anesthetized rats, Tianeptine blocks stress-induced PB inhibition in the basolateral amygdala's CA1 region without affecting stress-induced LTP enhancement. Tianeptine administration under non-stress conditions enhances PB in the amygdala, hippocampus, and LTP in anesthetized rats. Tianeptine significantly decreases cell apoptosis in the rat temporal cortex and hippocampal dentate gyrus in both control and stressed animals but does not affect the Ammons horn. It notably increases extracellular concentrations of homovanillic acid and vanilmandelic acid in the nucleus accumbens and striatum. Intraperitoneal injection of 2.5 mg/kg Tianeptine in the nucleus accumbens alone increases extracellular dopamine.
Synonyms	Tianeptine sodium

Chemical Properties

Molecular Weight	458.93
Formula	C₂₁H₂₄ClN₂NaO₄S
Cas No.	30123-17-2
Smiles	CN1c2ccccc2C(c2c(S1(=O)=O)cc(cc2)Cl)NCCCCCCC(=O)[O-].[Na+]
Relative Density.	1.38 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 45.9 mg/mL (100.02 mM), Sonication is recommended.

DMSO: 4.6 mg/mL (10.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.1790 mL	10.8949 mL	21.7898 mL	108.9491 mL
5 mM	0.4358 mL	2.1790 mL	4.3580 mL	21.7898 mL
10 mM	0.2179 mL	1.0895 mL	2.1790 mL	10.8949 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.1089 mL	0.5447 mL	1.0895 mL	5.4475 mL
50 mM	0.0436 mL	0.2179 mL	0.4358 mL	2.1790 mL
100 mM	0.0218 mL	0.1089 mL	0.2179 mL	1.0895 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc