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SB-200646A

Name: SB-200646A
Brand: TargetMol
SKU: T22423
Rating: 4.5 (1 reviews)

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Catalog No. T22423Cas No. 143797-62-0

SB-200646A is an orally active, selective antagonist of 5-HT2B/2C over 5-HT2A receptor with pKi of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively. SB-200646A exerts anxiolytic and electrophysiological properties in vivo.

SB-200646A

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Catalog No. T22423Cas No. 143797-62-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$35	5 days	5 days
1 mL x 10 mM (in DMSO)	$76	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	SB-200646A is an orally active, selective antagonist of 5-HT2B/2C over 5-HT2A receptor with pKi of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively. SB-200646A exerts anxiolytic and electrophysiological properties in vivo.
Targets&IC50	5-HT2A receptor:5.2 (pKi), 5-HT2C receptor:6.9 (pKi), 5-HT2B receptor:7.5 (pKi)
In vitro	SB200646A (4 μM) eliminates the increase in miniature inhibitory postsynaptic current (mIPSC) frequency induced by ethanol, without affecting the basal mIPSC frequency.
In vivo	SB-200646A (20 mg/kg; intravenous injection; daily; for 21 days; male albino Sprague-Dawley rats) significantly decreases the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons. Intravenous administration of 4-16 mg/kg of SB-200646A significantly increases the firing rate and percentage of events as bursts in spontaneously active VTA dopaminergic neurons and increases the percentage of events as burst in substantia nigra pars compacta (SNC) dopaminergic neurons[1].

Chemical Properties

Molecular Weight	302.76
Formula	C₁₅H₁₅ClN₄O
Cas No.	143797-62-0
Smiles	Cl.Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (743.16 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3029 mL	16.5147 mL	33.0295 mL	165.1473 mL
5 mM	0.6606 mL	3.3029 mL	6.6059 mL	33.0295 mL
10 mM	0.3303 mL	1.6515 mL	3.3029 mL	16.5147 mL
20 mM	0.1651 mL	0.8257 mL	1.6515 mL	8.2574 mL
50 mM	0.0661 mL	0.3303 mL	0.6606 mL	3.3029 mL
100 mM	0.0330 mL	0.1651 mL	0.3303 mL	1.6515 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc