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RS-67333

Name: RS-67333
Brand: TargetMol
SKU: T24742
Price: 293 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24742Cas No. 160845-95-4

Alias RS67333

RS-67333 is a selective and efficient partial agonist of the 5-HT4 receptor (5-HT4R) with neuroprotective effects, useful in preventing amyloid deposition and behavioral deficits in the 5XFAD mouse model of Alzheimer's disease.

RS-67333

🥰Excellent

Purity: 99.24%

Catalog No. T24742Alias RS67333Cas No. 160845-95-4

Pack Size	Price	Availability	Quantity
1 mg	$293	In Stock
5 mg	$722	In Stock

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Purity:99.24%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	RS-67333 is a selective and efficient partial agonist of the 5-HT4 receptor (5-HT4R) with neuroprotective effects, useful in preventing amyloid deposition and behavioral deficits in the 5XFAD mouse model of Alzheimer's disease.
Targets&IC50	5-HT4 receptor:8.7 (pKi)
In vitro	RS-67333 exhibits affinity for the 5-HT4 binding site in the guinea pig striatum (pKi = 8.7, respectively); and lower affinity (< 6.0) for several other receptors, including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1, D2, and muscarinic M1-M3 receptors. However, RS-67333 exhibits affinity for both the sigma 1 (pKi = 8.9) and sigma 2 (pKi = 8.0) binding sites.[1]
Synonyms	RS67333

Chemical Properties

Molecular Weight	352.9
Formula	C₁₉H₂₉ClN₂O₂
Cas No.	160845-95-4
Smiles	O=C(C=1C=C(Cl)C(N)=CC1OC)CCC2CCN(CCCC)CC2
Relative Density.	1.103g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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