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(Iso)-Fosdevirine
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Catalog No. T31860LCas No. 2869918-45-4
Alias (Iso)-GSK2248761, (Iso)-Fosdevirine（Iso-1018450-26-4）
(Iso)-Fosdevirine ( (Iso)-GSK2248761) is a selective and potent non-nucleoside reverse transcriptase (NNRTI) inhibitor with anti-HIV activity for the study of neurological disorders such as late-onset epilepsy.
(Iso)-Fosdevirine
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Purity: 99.93%
Catalog No. T31860LAlias (Iso)-GSK2248761, (Iso)-Fosdevirine（Iso-1018450-26-4）Cas No. 2869918-45-4
(Iso)-Fosdevirine ( (Iso)-GSK2248761) is a selective and potent non-nucleoside reverse transcriptase (NNRTI) inhibitor with anti-HIV activity for the study of neurological disorders such as late-onset epilepsy.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | In Stock | In Stock | |
| 5 mg | $483 | In Stock | In Stock | |
| 10 mg | $692 | In Stock | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,490 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.93%
ee:100%
Appearance:Solid
Color:White
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Product Introduction
(Iso)-Fosdevirine AI Summary
(Iso)-Fosdevirine exhibits notable bioactivity relevant to multiple pharmacokinetic parameters, including apparent total plasma clearance, oral bioavailability, half-life, maximum plasma concentration (Cmax), trough plasma concentration, volume of distribution, protein binding, and area under the curve (AUC). This compound also displays toxicity at varying doses, with activity percentages ranging from 0.0% to 43.8%. In terms of antiviral effectiveness, (Iso)-Fosdevirine shows potent inhibition against HIV1 with different mutations in the reverse transcriptase enzyme, displaying IC50 values as low as 0.08 nM and up to 11000.0 nM in various mutant strains. Specifically, it demonstrates antiviral activity against wild-type HIV1 infected in human MT4 cells as well as mutant strains carrying Y181C, K103N, and Y181C/K103N mutations, with EC50 values ranging from 2.9 nM to 16.6 nM. Additionally, (Iso)-Fosdevirine exhibits antiviral activity against SARS-CoV-2, where it inhibits virus-induced cytotoxicity in VERO-6 cells with an IC50 value greater than 20000.0 nM after 48 hours of exposure..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | (Iso)-Fosdevirine ( (Iso)-GSK2248761) is a selective and potent non-nucleoside reverse transcriptase (NNRTI) inhibitor with anti-HIV activity for the study of neurological disorders such as late-onset epilepsy. |
| Synonyms | (Iso)-GSK2248761, (Iso)-Fosdevirine（Iso-1018450-26-4） |
| Molecular Weight | 413.79 |
| Formula | C20H17ClN3O3P |
| Cas No. | 2869918-45-4 |
| Smiles | P(OC)(=O)(C=1C=2C(NC1C(N)=O)=CC=C(Cl)C2)C3=CC(/C=C/C#N)=CC(C)=C3 |
| Relative Density. | 1.42 g/cm3 at 20℃ (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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