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MK-0448 is a novel and selective blocker of the Kv1.5 (KCNA5) channel, a key channel involved in cardiac repolarization that is associated with atrial-specific ultra-rapid K+ current I Kur.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 1-2 weeks | |
50 mg | $1,980 | 1-2 weeks | |
100 mg | $2,500 | 1-2 weeks |
Description | MK-0448 is a novel and selective blocker of the Kv1.5 (KCNA5) channel, a key channel involved in cardiac repolarization that is associated with atrial-specific ultra-rapid K+ current I Kur. |
In vitro | In vitro studies of MK-0448 demonstrated potent inhibition of I(Kur) with minimal off-target activity. [1] |
In vivo | In vivo studies of MK-0448 in normal anesthetized dogs demonstrated a significant prolongation of atrial refractory period compared to vehicle controls, without affecting ventricular refractory period. In studies in a heart failure model in conscious dogs, persistent atrial fibrillation was terminated by bolus injections of MK-0448 at doses of 0.03 and 0.1 mg/kg.[1] |
Alias | MK0448 |
Molecular Weight | 448.51 |
Formula | C24H21FN4O2S |
Cas No. | 875562-81-5 |
Smiles | [C@@H]([C@H](C=1C=CC=NC1)C=2C=CC=NC2)(C=3N=C(NS(C)(=O)=O)C=CC3)C4=CC=C(F)C=C4 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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