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GW 766994

Name: GW 766994
Brand: TargetMol
SKU: T11521
Rating: 4.5 (1 reviews)

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Catalog No. T11521Cas No. 408303-43-5

Alias GW994, GW766994, GW 994

GW 766994 is a selective, orally active CCR3 (chemokine receptor-3) antagonist (Ki=13.8 nM) with anti-inflammatory effects, suitable for studying asthma and eosinophilic bronchitis.

GW 766994

😃Good

Purity: 98.77%

Catalog No. T11521Alias GW994, GW766994, GW 994Cas No. 408303-43-5

GW 766994 is a selective, orally active CCR3 (chemokine receptor-3) antagonist (Ki=13.8 nM) with anti-inflammatory effects, suitable for studying asthma and eosinophilic bronchitis.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,200	6-8 weeks	6-8 weeks
50 mg	$1,560	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.77%

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COA

Product Introduction

Bioactivity

Description	GW 766994 is a selective, orally active CCR3 (chemokine receptor-3) antagonist (Ki=13.8 nM) with anti-inflammatory effects, suitable for studying asthma and eosinophilic bronchitis.
Targets&IC50	CCR3:7.86 (pki)
In vitro	CCL11 treatment leads to the activation of CDK5 and GSK3β in hippocampal neurons, increased phosphorylation of tau protein at multiple sites, significantly elevated secretion of Aβ1-42, and a marked reduction in dendritic spine density. These effects were blocked by the CCR3-specific antagonist GW 766994 (10 μM) [2].
Synonyms	GW994, GW766994, GW 994

Chemical Properties

Molecular Weight	451.35
Formula	C₂₁H₂₄Cl₂N₄O₃
Cas No.	408303-43-5
Smiles	NC(=O)c1ccc(CNC(=O)NC[C@H]2CN(Cc3ccc(Cl)c(Cl)c3)CCO2)cc1
Relative Density.	1.331 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (88.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (4.43 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2156 mL	11.0779 mL	22.1558 mL	110.7788 mL
5 mM	0.4431 mL	2.2156 mL	4.4312 mL	22.1558 mL
10 mM	0.2216 mL	1.1078 mL	2.2156 mL	11.0779 mL
20 mM	0.1108 mL	0.5539 mL	1.1078 mL	5.5389 mL
50 mM	0.0443 mL	0.2216 mL	0.4431 mL	2.2156 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc