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GW 766994

Name: GW 766994
Brand: TargetMol
SKU: T11521
Rating: 4.5 (1 reviews)

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Catalog No. T11521Cas No. 408303-43-5

Alias GW994, GW766994, GW 994

GW 766994 is a selective, orally active CCR3 (chemokine receptor-3) antagonist (Ki=13.8 nM) with anti-inflammatory effects, suitable for studying asthma and eosinophilic bronchitis.

GW 766994

😃Good

Purity: 98.77%

Catalog No. T11521Alias GW994, GW766994, GW 994Cas No. 408303-43-5

GW 766994 is a selective, orally active CCR3 (chemokine receptor-3) antagonist (Ki=13.8 nM) with anti-inflammatory effects, suitable for studying asthma and eosinophilic bronchitis.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,200	6-8 weeks	6-8 weeks
50 mg	$1,560	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.77%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	GW 766994 is a selective, orally active CCR3 (chemokine receptor-3) antagonist (Ki=13.8 nM) with anti-inflammatory effects, suitable for studying asthma and eosinophilic bronchitis.
Targets&IC50	CCR3:7.86 (pki)
In vitro	CCL11 treatment leads to the activation of CDK5 and GSK3β in hippocampal neurons, increased phosphorylation of tau protein at multiple sites, significantly elevated secretion of Aβ1-42, and a marked reduction in dendritic spine density. These effects were blocked by the CCR3-specific antagonist GW 766994 (10 μM) [2].
Synonyms	GW994, GW766994, GW 994

Chemical Properties

Molecular Weight	451.35
Formula	C₂₁H₂₄Cl₂N₄O₃
Cas No.	408303-43-5
Smiles	NC(=O)c1ccc(CNC(=O)NC[C@H]2CN(Cc3ccc(Cl)c(Cl)c3)CCO2)cc1
Relative Density.	1.331 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (88.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (4.43 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2156 mL	11.0779 mL	22.1558 mL	110.7788 mL
5 mM	0.4431 mL	2.2156 mL	4.4312 mL	22.1558 mL
10 mM	0.2216 mL	1.1078 mL	2.2156 mL	11.0779 mL
20 mM	0.1108 mL	0.5539 mL	1.1078 mL	5.5389 mL
50 mM	0.0443 mL	0.2216 mL	0.4431 mL	2.2156 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc