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GSK269962A hydrochloride
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Catalog No. T39519Cas No. 2095432-71-4
Alias GSK269962 hydrochloride, GSK 269962A hydrochloride, GSK 269962 hydrochloride
GSK269962A hydrochloride (GSK 269962 hydrochloride) is a potent and selective ROCK inhibitor with anti-inflammatory and vasodilatory effects, inhibits ROCK1 and ROCK2, and can be used in the study of acute myeloid leukemias.
GSK269962A hydrochloride
Copy Product Info😃Good
Catalog No. T39519Alias GSK269962 hydrochloride, GSK 269962A hydrochloride, GSK 269962 hydrochlorideCas No. 2095432-71-4
GSK269962A hydrochloride (GSK 269962 hydrochloride) is a potent and selective ROCK inhibitor with anti-inflammatory and vasodilatory effects, inhibits ROCK1 and ROCK2, and can be used in the study of acute myeloid leukemias.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $37 | - | In Stock | |
| 5 mg | Preferential | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Appearance:Solid
Color:White
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| Description | GSK269962A hydrochloride (GSK 269962 hydrochloride) is a potent and selective ROCK inhibitor with anti-inflammatory and vasodilatory effects, inhibits ROCK1 and ROCK2, and can be used in the study of acute myeloid leukemias. |
| Targets&IC50 | CDK2:3500 nM, MSK1:49 nM, ROCK2:4 nM, vasodilatation (preconstricted rat aortas:35 nM, GSK-3α:1260 nM, ROCK1 (human):1.6 nM, RSK1:132 nM, AKT2:1350 nM, AKT3:1510 nM, AKT1:955 nM |
| In vitro | GSK269962A hydrochloride is a potent ROCK inhibitor with IC50s of 1.6 nM and 4 nM for recombinant human ROCK1 and ROCK2, respectively. GSK269962A hydrochloride induced vasodilatation in preconstricted rat aortas with an IC50 of 35 nM.[1] |
| In vivo | GSK269962A hydrochloride (0.3, 1 and 3 mg/kg by gavage) induced a dose-dependent decrease in blood pressure in spontaneously hypertensive rats (SHR), with a rapid and significant antihypertensive effect. [1] |
| Synonyms | GSK269962 hydrochloride, GSK 269962A hydrochloride, GSK 269962 hydrochloride |
| Molecular Weight | 607.06 |
| Formula | C29H31ClN8O5 |
| Cas No. | 2095432-71-4 |
| Smiles | Cl.O=C(NC=1C=CC=C(OC2=NC=C3N=C(C4=NON=C4N)N(C3=C2)CC)C1)C5=CC=C(OCCN6CCOCC6)C=C5 |
| Relative Density. | no data available |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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