Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK269962A hydrochloride (GSK 269962 hydrochloride) is a highly potent inhibitor of ROCK1 and ROCK2, with IC50 values of 1.6 nM and 4 nM, respectively, for recombinant human isoforms. This compound exhibits both anti-inflammatory and vasodilatory properties.
Pack Size | Availability | Price/USD | Quantity |
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5 mg | 5 days | $ 970.00 |
Description | GSK269962A hydrochloride (GSK 269962 hydrochloride) is a highly potent inhibitor of ROCK1 and ROCK2, with IC50 values of 1.6 nM and 4 nM, respectively, for recombinant human isoforms. This compound exhibits both anti-inflammatory and vasodilatory properties. |
Targets&IC50 | MSK1:49 nM (IC50), Akt3:1510 nM (IC50), ROCK1:1.6 nM (IC50), ROCK2:4 nM (IC50), CDK2:3500 nM (IC50), Akt2:1350 nM (IC50), GSK-3α:1260 nM (IC50), Akt1:955 nM (IC50), RSK1:132 nM (IC50) |
In vitro | GSK269962A, with an IC50 of 1.6 nM, targets recombinant human ROCK1 and demonstrates over 30-fold selectivity against a panel of serine/threonine kinases[1]. Additionally, it induces vasorelaxation in preconstricted rat aorta, achieving an IC50 of 35 nM[1]. |
In vivo | GSK269962A is an effective antihypertensive compound. Administered through oral gavage at dosages of 0.3, 1, and 3 mg/kg, GSK269962A demonstrates a dose-dependent decrease in blood pressure in spontaneously hypertensive rats (SHR), showing both acute and significant effects. The study utilized male Sprague-Dawley rats, weighing 350-400g, and observed these blood pressure reductions at 12 hours post-administration. |
Synonyms | GSK 269962 hydrochloride |
Molecular Weight | 607.06 |
Formula | C29H31ClN8O5 |
CAS No. | 2095432-71-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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GSK269962A hydrochloride 2095432-71-4 GSK269962 Hydrochloride GSK-269962 Hydrochloride GSK 269962 Hydrochloride GSK269962A Hydrochloride GSK-269962A hydrochloride GSK 269962 hydrochloride inhibitor inhibit