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GDC-2394 sodium salt
🥰Excellent
Catalog No. T69745LCas No. 2238822-08-5
Alias GDC2394 sodium salt
GDC-2394 sodium salt is an orally active selective NLRP3 inhibitor that concurrently inhibits IL-1β with IC50 values of 0.4 μM (human) and 0.1 μM (mouse). This compound specifically inhibits NLRP3-induced caspase-1 activity without affecting NLRC4-dependent inflammasome activation.
GDC-2394 sodium salt
🥰Excellent
Purity: 99.50%
Catalog No. T69745LAlias GDC2394 sodium saltCas No. 2238822-08-5
GDC-2394 sodium salt is an orally active selective NLRP3 inhibitor that concurrently inhibits IL-1β with IC50 values of 0.4 μM (human) and 0.1 μM (mouse). This compound specifically inhibits NLRP3-induced caspase-1 activity without affecting NLRC4-dependent inflammasome activation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $195 | In Stock | |
| 5 mg | $483 | In Stock | |
| 10 mg | $691 | In Stock | |
| 25 mg | $1,080 | In Stock | |
| 50 mg | $1,490 | In Stock | |
| 100 mg | $1,960 | In Stock |
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Purity:99.50%
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Product Introduction
Bioactivity
Chemical Properties
| Description | GDC-2394 sodium salt is an orally active selective NLRP3 inhibitor that concurrently inhibits IL-1β with IC50 values of 0.4 μM (human) and 0.1 μM (mouse). This compound specifically inhibits NLRP3-induced caspase-1 activity without affecting NLRC4-dependent inflammasome activation. |
| In vivo | GDC-2394 sodium salt (25 mg/kg, intravenous injection, 7 days) was used to treat a functional rat model of gouty arthritis and significantly inhibited knee joint swelling after 48 hours.[1] |
| Synonyms | GDC2394 sodium salt |
| Molecular Weight | 453.49 |
| Formula | C20H24N5NaO4S |
| Cas No. | 2238822-08-5 |
| Smiles | [Na+].CN[C@@H]1COC2=C(C=NN2C1)S(=O)(=O)[N-]C(=O)NC1=C2CCCC2=CC2=C1CCC2 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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