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NBQX disodium

Name: NBQX disodium
Brand: TargetMol
SKU: T25853
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T25853Cas No. 479347-86-9

Alias NBQX 2Na, FG9202 disodium

NBQX disodium is a highly selective, competitive AMPA receptor antagonist with neuroprotective and anticonvulsant activity. NBQX disodium is a salt of NBQX. NBQX disodium is a potent and selective AMPA/rhodosinate receptor antagonist that can be used to antagonize the excitatory toxicity of glutamate. It has anticonvulsant effects in rodent models.

NBQX disodium

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Purity: 97.6%

Catalog No. T25853Alias NBQX 2Na, FG9202 disodiumCas No. 479347-86-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$80	In Stock	In Stock
10 mg	$123	In Stock	In Stock
25 mg	$247	In Stock	In Stock
50 mg	$372	In Stock	In Stock
100 mg	$558	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$88	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:97.6%

Appearance:Solid

Color:Yellow to Brown

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	NBQX disodium is a highly selective, competitive AMPA receptor antagonist with neuroprotective and anticonvulsant activity. NBQX disodium is a salt of NBQX. NBQX disodium is a potent and selective AMPA/rhodosinate receptor antagonist that can be used to antagonize the excitatory toxicity of glutamate. It has anticonvulsant effects in rodent models.
Targets&IC50	AMPA:0.7 ± 0.1 μM, Kainic acid:0.7 ± 0.03 μM
In vitro	In HIP-009 cells, NBQX disodium salt inhibited both AMPA or kainic acid (KA) induced signals in a concentration-dependent manner, with IC50 values being 0.7 ± 0.1 and 0.7 ± 0.03 μM, respectively. The AMPA-evoked calcium rise was completely inhibited by NBQX disodium salt, whereas 68.6% ± 1.3% inhibition of the KA-induced signal was observed with 30 μM of NBQX disodium salt treatment.[1]
In vivo	Administration of NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) exhibits a reduction in PTZ-induced seizures. [2] In a rat model of focal ischemia, NBQX disodium demonstrates neuroprotective effects when administered intravenously as a bolus dose of 30 mg/kg at the time of MCA occlusion, followed by an additional dose at 1 hour post-occlusion. [3]
Synonyms	NBQX 2Na, FG9202 disodium

Chemical Properties

Molecular Weight	380.2415
Formula	C₁₂H₆N₄Na₂O₆S
Cas No.	479347-86-9
Smiles	O=C1[N-]C2=C([N-]C1=O)C3=CC=CC(S(=O)(N)=O)=C3C([N+]([O-])=O)=C2.[Na+].[Na+]

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 30 mg/mL (78.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.6299 mL	13.1495 mL	26.2991 mL	131.4954 mL
5 mM	0.5260 mL	2.6299 mL	5.2598 mL	26.2991 mL
10 mM	0.2630 mL	1.3150 mL	2.6299 mL	13.1495 mL
20 mM	0.1315 mL	0.6575 mL	1.3150 mL	6.5748 mL
50 mM	0.0526 mL	0.2630 mL	0.5260 mL	2.6299 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc