store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NDB is a selective and potent hFXRα antagonist that inhibits GW4064-stimulated FXR/RXR interactions and FXRα target gene expression in primary mouse hepatocytes.NDB is used in the study of diabetes.
Description | NDB is a selective and potent hFXRα antagonist that inhibits GW4064-stimulated FXR/RXR interactions and FXRα target gene expression in primary mouse hepatocytes.NDB is used in the study of diabetes. |
In vitro | NDB induces rearrangements of helix 11 (H11) and helix 12 (H12, AF-2) by forming a homodimer of hFXRα-LBD, which is totally different from the active conformation in the monomer state[1]. Additionally, at a concentration of 25 μM, NDB effectively antagonizes the GW4064-stimulated FXR/RXR interaction and FXRα target gene expression in primary mouse hepatocytes. This includes the small heterodimer partner (SHP) and bile-salt export pump (BSEP)[1]. |
In vivo | Administered through intraperitoneal injection at a dosage of 24 mg/kg once a day for a duration of 4 weeks, NDB efficiently decreases the gene expressions of phosphoenolpyruvate carboxykinase (PEPCK), glucose 6-phosphatase (G6-pase), small heterodimer partner, and bile-salt export pump (BSEP) in db/db mice[1]. |
Molecular Weight | 471.42 |
Formula | C26H28Cl2N2O2 |
CAS No. | 1660153-08-1 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (169.70 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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NDB 1660153-08-1 Metabolism FXR inhibitor inhibit