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ED11

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Catalog No. TP3043Cas No. 1593480-56-8

ED11 is a potent and selective caspase-6 inhibitor with an IC50 of 12.12 nM. It competes with Htt for the caspase-6 active site, thereby reducing Htt cleavage. ED11 is capable of crossing the blood-brain barrier (BBB) and holds potential for researching Huntington's disease (HD).

ED11

ED11

😃Good
Catalog No. TP3043Cas No. 1593480-56-8
ED11 is a potent and selective caspase-6 inhibitor with an IC50 of 12.12 nM. It competes with Htt for the caspase-6 active site, thereby reducing Htt cleavage. ED11 is capable of crossing the blood-brain barrier (BBB) and holds potential for researching Huntington's disease (HD).
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Product Introduction

Bioactivity
Description
ED11 is a potent and selective caspase-6 inhibitor with an IC50 of 12.12 nM. It competes with Htt for the caspase-6 active site, thereby reducing Htt cleavage. ED11 is capable of crossing the blood-brain barrier (BBB) and holds potential for researching Huntington's disease (HD).
Chemical Properties
Molecular Weight2850.16
FormulaC116H205N47O37
Cas No.1593480-56-8
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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