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RN9893

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Catalog No. T28548Cas No. 1803003-68-0

Alias RN-9893, RN 9893

RN9893 is a selective and potent TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for TRPV4 receptors in mouse, human and rat, respectively.

RN9893

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Purity: 99.99%

Catalog No. T28548Alias RN-9893, RN 9893Cas No. 1803003-68-0

RN9893 is a selective and potent TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for TRPV4 receptors in mouse, human and rat, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	-	In Stock
5 mg	$89	-	In Stock
10 mg	$147	-	In Stock
25 mg	$228	-	In Stock
50 mg	$342	-	In Stock
100 mg	$497	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.99%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

RN9893 AI Summary

RN9893 displays a variety of bioactivities based on assay data. It shows moderate to high binding affinity to multiple serotonin receptors with varying levels of inhibition and exhibits antagonist activity at TRPV4 receptors across different species. It also has antagonistic effects on select adrenergic receptors. Additionally, the compound has notable plasma protein binding affinity and solubility at pH 7.4. Its bioavailability and pharmacokinetic parameters, including AUC, Cmax, and half-life, have been assessed in Wistar rats through various administration routes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	RN9893 is a selective and potent TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for TRPV4 receptors in mouse, human and rat, respectively.
Targets&IC50	TRPV4 (rat):660 nM, TRPV4 (mouse):320 nM, TRPV4 (human):420 nM
Synonyms	RN-9893, RN 9893

Chemical Properties

Molecular Weight	500.49
Formula	C₂₁H₂₃F₃N₄O₅S
Cas No.	1803003-68-0
Smiles	C(NC1=CC=C(S(=O)(=O)N2CCN(C(C)C)CC2)C=C1)(=O)C3=C(N(=O)=O)C=C(C(F)(F)F)C=C3
Relative Density.	1.421 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (399.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9980 mL	9.9902 mL	19.9804 mL	99.9021 mL
5 mM	0.3996 mL	1.9980 mL	3.9961 mL	19.9804 mL
10 mM	0.1998 mL	0.9990 mL	1.9980 mL	9.9902 mL
20 mM	0.0999 mL	0.4995 mL	0.9990 mL	4.9951 mL
50 mM	0.0400 mL	0.1998 mL	0.3996 mL	1.9980 mL
100 mM	0.0200 mL	0.0999 mL	0.1998 mL	0.9990 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc