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GLL 398

Name: GLL 398
Brand: TargetMol
SKU: T9997
Rating: 4.5 (1 reviews)

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Catalog No. T9997Cas No. 2077980-80-2

GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models.

GLL 398

😃Good

Catalog No. T9997Cas No. 2077980-80-2

GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$195	Inquiry	Inquiry
5 mg	$437	Inquiry	Inquiry
10 mg	$655	Inquiry	Inquiry
25 mg	$1,178	Inquiry	Inquiry
50 mg	$1,768	Inquiry	Inquiry
100 mg	$2,652	Inquiry	Inquiry
200 mg	$3,978	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$447	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models.
In vitro	GLL398 exhibits a strong dose-dependent binding profile for the estrogen receptor with a Y537S point mutation with an IC50 of 29.5 nM[1].

Chemical Properties

Molecular Weight	398.26
Formula	C₂₅H₂₃BO₄
Cas No.	2077980-80-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (615.18 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5109 mL	12.5546 mL	25.1092 mL	125.5461 mL
5 mM	0.5022 mL	2.5109 mL	5.0218 mL	25.1092 mL
10 mM	0.2511 mL	1.2555 mL	2.5109 mL	12.5546 mL
20 mM	0.1255 mL	0.6277 mL	1.2555 mL	6.2773 mL
50 mM	0.0502 mL	0.2511 mL	0.5022 mL	2.5109 mL
100 mM	0.0251 mL	0.1255 mL	0.2511 mL	1.2555 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc