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GLL 398

Name: GLL 398
Brand: TargetMol
SKU: T9997
Rating: 4.5 (1 reviews)

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Catalog No. T9997Cas No. 2077980-80-2

GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models.

GLL 398

😃Good

Catalog No. T9997Cas No. 2077980-80-2

GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$195	Inquiry	Inquiry
5 mg	$437	Inquiry	Inquiry
10 mg	$655	Inquiry	Inquiry
25 mg	$1,178	Inquiry	Inquiry
50 mg	$1,768	Inquiry	Inquiry
100 mg	$2,652	Inquiry	Inquiry
200 mg	$3,978	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$447	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models.
In vitro	GLL398 exhibits a strong dose-dependent binding profile for the estrogen receptor with a Y537S point mutation with an IC50 of 29.5 nM[1].

Chemical Properties

Molecular Weight	398.26
Formula	C₂₅H₂₃BO₄
Cas No.	2077980-80-2
Smiles	CC/C(C1=CC=CC=C1)=C(C2=CC=C(B(O)O)C=C2)/C3=CC=C(C=C3)/C=C/C(O)=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (615.18 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5109 mL	12.5546 mL	25.1092 mL	125.5461 mL
5 mM	0.5022 mL	2.5109 mL	5.0218 mL	25.1092 mL
10 mM	0.2511 mL	1.2555 mL	2.5109 mL	12.5546 mL
20 mM	0.1255 mL	0.6277 mL	1.2555 mL	6.2773 mL
50 mM	0.0502 mL	0.2511 mL	0.5022 mL	2.5109 mL
100 mM	0.0251 mL	0.1255 mL	0.2511 mL	1.2555 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc