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HBV-IN-45

🥰Excellent
Catalog No. T209597

HBV-IN-45 is a selective and orally bioavailable HBV capsid assembly modulator, with an IC50 of 0.51 μM for HBcAg in HBC cells. [HBV-IN-45] demonstrates potent anti-HBV activity.

HBV-IN-45

HBV-IN-45

🥰Excellent
Catalog No. T209597
HBV-IN-45 is a selective and orally bioavailable HBV capsid assembly modulator, with an IC50 of 0.51 μM for HBcAg in HBC cells. [HBV-IN-45] demonstrates potent anti-HBV activity.
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Product Introduction

Bioactivity
Description
HBV-IN-45 is a selective and orally bioavailable HBV capsid assembly modulator, with an IC50 of 0.51 μM for HBcAg in HBC cells. [HBV-IN-45] demonstrates potent anti-HBV activity.
In vitro
HBV-IN-45 (compound 26f) inhibits the growth of HepG2 cells, with a CC₅₀ of 84.29 μM. Additionally, it suppresses HBV DNA in the supernatant of HepAD38 cells, demonstrating an EC₅₀ of 2.24 μM.
In vivo
HBV-IN-45 (compound 26f; 100 mg/kg; oral administration; twice daily for 14 days) effectively reduces HBV DNA levels in plasma without altering the levels of HBeAg in mouse serum or the liver enzyme GPT (ALT).
Chemical Properties
FormulaC16H16N2O2S
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: buy HBV-IN-45 | purchase HBV-IN-45 | HBV-IN-45 cost | order HBV-IN-45 | HBV-IN-45 in vivo | HBV-IN-45 in vitro | HBV-IN-45 formula
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