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LY2812223

Name: LY2812223
Brand: TargetMol
SKU: T15809
Rating: 4.5 (1 reviews)

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Catalog No. T15809Cas No. 1311385-20-2

LY2812223 is a highly effective and functionally selective mGlu2 receptor agonist. It has a mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively).

LY2812223

😃Good

Catalog No. T15809Cas No. 1311385-20-2

LY2812223 is a highly effective and functionally selective mGlu2 receptor agonist. It has a mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively).

Pack Size	Price	Availability
25 mg	Inquiry	3-6 months
50 mg	Inquiry	3-6 months
100 mg	Inquiry	3-6 months

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	LY2812223 is a highly effective and functionally selective mGlu2 receptor agonist. It has a mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively).
Targets&IC50	mGluR2:144 nM (ki), mGluR3:156 nM (ki)

Chemical Properties

Molecular Weight	284.29
Formula	C₁₀H₁₂N₄O₄S
Cas No.	1311385-20-2
Relative Density.	1.78 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (175.88 mM), Sonication is recommended.

DMSO: 28.75 mg/mL (101.13 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.5175 mL	17.5877 mL	35.1753 mL	175.8767 mL
5 mM	0.7035 mL	3.5175 mL	7.0351 mL	35.1753 mL
10 mM	0.3518 mL	1.7588 mL	3.5175 mL	17.5877 mL
20 mM	0.1759 mL	0.8794 mL	1.7588 mL	8.7938 mL
50 mM	0.0704 mL	0.3518 mL	0.7035 mL	3.5175 mL
100 mM	0.0352 mL	0.1759 mL	0.3518 mL	1.7588 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc