Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AP-C5 is a compound with selective inhibition of guanosine 3',5' cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII), with a Pic50 value of 7.2 for cGMP, and can be used in the study of diarrheal diseases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 51.00 | |
10 mg | In stock | $ 89.00 | |
25 mg | In stock | $ 178.00 | |
50 mg | In stock | $ 293.00 | |
100 mg | In stock | $ 476.00 |
Description | AP-C5 is a compound with selective inhibition of guanosine 3',5' cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII), with a Pic50 value of 7.2 for cGMP, and can be used in the study of diarrheal diseases. |
Targets&IC50 | cGKII:7.2 |
In vitro |
AP-C5 (50 μM; T84 cells) potentiates cAMP signaling by PDE inhibition.[1] AP-C5 (10−9 and 3·10−4 mol/L) shows potent inhibition of cGMP-dependent cGKII-mediated protein phosphorylation and effective inhibition of cGMP-dependent, CFTR-mediated anion secretion in intestinal tissue.[1] AP-C5 (20 μM) partially blocks the heat-stable toxin (STa)-mediated short-circuit current (Isc) response in mouse ileum.[1] |
Molecular Weight | 275.31 |
Formula | C16H13N5 |
CAS No. | 2234272-10-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (81.7 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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AP-C5 2234272-10-5 Microbiology/Virology Parasite inhibitor inhibit