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αA-Conotoxin PIVA

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Catalog No. T80486Cas No. 171439-59-1

αA-Conotoxin PIVA serves as a selective inhibitor of mouse muscle nicotinic acetylcholine receptors (nAChRs), demonstrating half-maximal inhibitory concentrations (IC50) of 2.3 nM for adult and 22 nM for fetal mouse muscle nAChRs. The compound is utilized in research related to neurological diseases.

αA-Conotoxin PIVA

αA-Conotoxin PIVA

😃Good
Catalog No. T80486Cas No. 171439-59-1
αA-Conotoxin PIVA serves as a selective inhibitor of mouse muscle nicotinic acetylcholine receptors (nAChRs), demonstrating half-maximal inhibitory concentrations (IC50) of 2.3 nM for adult and 22 nM for fetal mouse muscle nAChRs. The compound is utilized in research related to neurological diseases.
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Product Introduction

Bioactivity
Description
αA-Conotoxin PIVA serves as a selective inhibitor of mouse muscle nicotinic acetylcholine receptors (nAChRs), demonstrating half-maximal inhibitory concentrations (IC50) of 2.3 nM for adult and 22 nM for fetal mouse muscle nAChRs. The compound is utilized in research related to neurological diseases.
Chemical Properties
Molecular Weight2648.89
FormulaC103H150N34O37S6
Cas No.171439-59-1
SequenceGly-Cys-Cys-Gly-Ser-Tyr-{Hyp}-Asn-Ala-Ala-Cys-His-{Hyp}-Cys-Ser-Cys-Lys-Asp-Arg-{Hyp}-Ser-Tyr-Cys-Gly-Gln-NH2 (Disulfide bridge:Cys2-Cys16, Cys3-Cys11, Cys14-Cys23)
Sequence ShortGCCGSY-{Hyp}-NAACH-{Hyp}-CSCKDR-{Hyp}-SYCGQ-NH2 (Disulfide bridge:Cys2-Cys16, Cys3-Cys11, Cys14-Cys23)
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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