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AMPK activator 4

Catalog No. T62238 CAS 2493239-46-4

AMPK activator 4 is a potent and selective AMPK activator that does not inhibit mitochondrial complex I. AMPK activator 4 selectively activates AMPK in muscle tissue and dose-dependently improves glucose tolerance in normal mice, significantly reduces fasting glucose levels and improves insulin resistance in db/db diabetic mice.AMPK activator 4 has hypoglycemic effects. activator 4 has hypoglycemic effects.

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AMPK activator 4, CAS 2493239-46-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 83.00
5 mg	In stock	$ 193.00
10 mg	In stock	$ 372.00
25 mg	In stock	$ 626.00
50 mg	In stock	$ 892.00
100 mg	In stock	$ 1,220.00
500 mg	In stock	$ 2,430.00
1 mL * 10 mM (in DMSO)	In stock	$ 226.00

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Purity: 99.75%

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Description	AMPK activator 4 is a potent and selective AMPK activator that does not inhibit mitochondrial complex I. AMPK activator 4 selectively activates AMPK in muscle tissue and dose-dependently improves glucose tolerance in normal mice, significantly reduces fasting glucose levels and improves insulin resistance in db/db diabetic mice.AMPK activator 4 has hypoglycemic effects. activator 4 has hypoglycemic effects.
In vitro	AMPK activator 4 (compound B10) (10-20 μM; 72 h) slightly decreases the viability of HepG2 cells.[1] AMPK activator 4 (0-20 μM; 12-24 h) induced dose-dependent phosphorylation of ACC in C2C12 myotube cells, and the phosphorylation of ACC was highly consistent with the phosphorylation of AMPK. Increased the phosphorylation of AMPK and ACC in human hepatocarcinoma HepG2 and HuH-7 cells.[1]
In vivo	AMPK activator 4 (100 mg/kg; Intragastrical administration; daily for 9 weeks; db/db mice) significantly lowered the fasting blood glucose in db/db mice (2-6 weeks). Significantly improved insulin resistance in db/db mice (for 9 weeks). The body weight and the serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) (two markers of liver injury) were not significantly affected. It shows an anti-hyperglycemic effect.[1]

Molecular Weight	420.89
Formula	C24H21ClN2O3
CAS No.	2493239-46-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225.0 mg/mL (534.6 mM), Sonication is recommended.

References and Literature

1. Sun G, et al. Discovery of AdipoRon analogues as novel AMPK activators without inhibiting mitochondrial complex I. Eur J Med Chem. 2020;200:112466.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Cancer Compound Library

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Keywords

AMPK activator 4 2493239-46-4 Chromatin/Epigenetic PI3K/Akt/mTOR signaling AMPK inhibitor inhibit

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