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Taprizosin

Name: Taprizosin
Brand: TargetMol
SKU: T28922
Price: 373 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28922Cas No. 210538-44-6

Alias UK-338003, UK338003, UK-338,003, UK 338003, Taprizosin Mesylate

Taprizosin(UK-338003) is a selective and orally active α1-adrenoceptor antagonist for vasodilatation in the treatment of benign prostatic hyperplasia.

Taprizosin

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Purity: 99.11%

Catalog No. T28922Alias UK-338003, UK338003, UK-338,003, UK 338003, Taprizosin MesylateCas No. 210538-44-6

Taprizosin(UK-338003) is a selective and orally active α1-adrenoceptor antagonist for vasodilatation in the treatment of benign prostatic hyperplasia.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$373	In Stock	In Stock
5 mg	$896	In Stock	In Stock
10 mg	$1,230	In Stock	In Stock
25 mg	$1,880	In Stock	In Stock
50 mg	$2,580	In Stock	In Stock
100 mg	$3,400	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.11%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Taprizosin AI Summary

Taprizosin is a molecule with moderate lipophilicity (LogD = 3.0) and a pKa of 6.7. It exhibits metabolic stability in both human and Beagle dog liver microsomes, presenting different half-lives and intrinsic clearance rates. The compound shows varying bioavailability and absorption rates depending on the animal model, such as Beagle dogs and Sprague-Dawley rats, and the route of administration, whether oral or intravenous. Additionally, it has significant protein binding in the plasma of Beagle dogs, Sprague-Dawley rats, and humans..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Taprizosin(UK-338003) is a selective and orally active α1-adrenoceptor antagonist for vasodilatation in the treatment of benign prostatic hyperplasia.
Synonyms	UK-338003, UK338003, UK-338,003, UK 338003, Taprizosin Mesylate

Chemical Properties

Molecular Weight	506.58
Formula	C₂₅H₂₆N₆O₄S
Cas No.	210538-44-6
Smiles	NC=1C=2C(=C(OC)C(OC)=CC2N=C(N1)N3CC=4C(CC3)=C(NS(C)(=O)=O)C=CC4)C5=CC=CC=N5
Relative Density.	1.401g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (118.44 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9740 mL	9.8701 mL	19.7402 mL	98.7011 mL
5 mM	0.3948 mL	1.9740 mL	3.9480 mL	19.7402 mL
10 mM	0.1974 mL	0.9870 mL	1.9740 mL	9.8701 mL
20 mM	0.0987 mL	0.4935 mL	0.9870 mL	4.9351 mL
50 mM	0.0395 mL	0.1974 mL	0.3948 mL	1.9740 mL
100 mM	0.0197 mL	0.0987 mL	0.1974 mL	0.9870 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc