Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

DNL343

TargetMol
DNL343
DNL343 is a selective and potent eIF2B activator that crosses the blood-brain barrier and inhibits the assembly of stress granules (SGs) induced by the C9ORF72 dipeptide repeats. DNL343 may be useful in the study of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS).
Catalog No. T78876Cas No. 2278265-85-1
Select Batch
Purity:100%
ee:100%
Contact us for more batch information

DNL343

TargetMol
Catalog No. T78876Cas No. 2278265-85-1

DNL343 is a selective and potent eIF2B activator that crosses the blood-brain barrier and inhibits the assembly of stress granules (SGs) induced by the C9ORF72 dipeptide repeats. DNL343 may be useful in the study of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$148In Stock
5 mg$372In Stock
10 mg$619In Stock
25 mg$1,230In Stock
50 mg$1,980In Stock
100 mg$3,280In Stock
Bulk & Custom
Add to Cart
Questions
View More

Product Introduction

Bioactivity
Description
DNL343 is a selective and potent eIF2B activator that crosses the blood-brain barrier and inhibits the assembly of stress granules (SGs) induced by the C9ORF72 dipeptide repeats. DNL343 may be useful in the study of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS).
AliasDNL-343, DNL 343
Chemical Properties
Molecular Weight457.83
FormulaC20H19ClF3N3O4
Cas No.2278265-85-1
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (174.74 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1842 mL10.9211 mL21.8422 mL109.2108 mL
5 mM0.4368 mL2.1842 mL4.3684 mL21.8422 mL
10 mM0.2184 mL1.0921 mL2.1842 mL10.9211 mL
20 mM0.1092 mL0.5461 mL1.0921 mL5.4605 mL
50 mM0.0437 mL0.2184 mL0.4368 mL2.1842 mL
100 mM0.0218 mL0.1092 mL0.2184 mL1.0921 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: buy DNL343 | purchase DNL343 | DNL343 cost | order DNL343 | DNL343 chemical structure | DNL343 formula | DNL343 molecular weight