Shopping Cart

Your shopping cart is currently empty

XL-3156

Name: XL-3156
Brand: TargetMol
SKU: T212003
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Synonyms:

Catalog No. T212003 Copy Product Info

Purity: 99.16%

🥰Excellent

XL-3156 is a potent, selective, and cross-species inhibitor of cGAS. XL-3156 simultaneously occupies allosteric and orthosteric sites, stabilizing the closed conformation of the activation loop to inhibit the interaction and phase separation of cGAS with DNA. XL-3156 is applicable in innate immune signaling research and is used to investigate cGAS–STING pathway regulation, DNA sensing mechanisms, and phase separation-dependent activation processes in autoimmune and inflammatory disease models.

Cas No. 3117797-30-2

Customer service consultation

Pack Size	Price	USA Stock	Global Stock
1 mg	$84	-	In Stock
5 mg	$198	-	In Stock
10 mg	$328	-	In Stock
25 mg	$619	-	In Stock
50 mg	$993	-	In Stock
100 mg	$1,490	-	In Stock
1 mL x 10 mM (in DMSO)	$235	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:99.16%

Appearance:Solid

Color:Orange

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

In vitro

Methods：Electrophoretic mobility shift assay (EMSA) and in vitro phase separation assays were performed. XL-3156 was applied at various concentrations for different durations to explore its effects on the interaction between h-cGAS and labeled DNA, as well as condensate formation and phase separation.
Results：
1.Treatment with 20 μM XL-3156 for 20 minutes inhibited the binding of purified h-cGASCD to Cy5-labeled ISD45 DNA.
2.XL-3156 at 4–100 μM blocked the phase separation of h-cGASCD and FAM-labeled ISD100 DNA in a dose-dependent manner.
3.Exposure to 50 μM XL-3156 for 20 minutes disrupted condensates formed by h-cGASCD and Cy3-labeled ISD100 DNA, with an EC₅₀ of 783 nM.
4.Incubation with 100 μM XL-3156 for 30 minutes markedly suppressed the in vitro phase separation of full-length h-cGASFL and Cy3-labeled ISD100 DNA.

Chemical Properties

Molecular Weight	517.54
Formula	C₂₈H₂₃N₉O₂
Cas No.	3117797-30-2
Smiles	OC1=C(C(C2=CC=CC=N2)C3=C(O)N(C4=NC5=C(C=CC=C5)N4)N=C3C)C(C)=NN1C6=NC7=CC=CC=C7N6
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (77.29 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9322 mL	9.6611 mL	19.3222 mL	96.6109 mL
5 mM	0.3864 mL	1.9322 mL	3.8644 mL	19.3222 mL
10 mM	0.1932 mL	0.9661 mL	1.9322 mL	9.6611 mL
20 mM	0.0966 mL	0.4831 mL	0.9661 mL	4.8305 mL
50 mM	0.0386 mL	0.1932 mL	0.3864 mL	1.9322 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: XL-3156 chemical structure | XL-3156 in vitro | XL-3156 formula | XL-3156 molecular weight