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ORM-10962

Name: ORM-10962
Brand: TargetMol
SKU: T12322
Rating: 4.5 (1 reviews)

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Catalog No. T12322Cas No. 763926-98-3

ORM-10962 is a potent and highly selective inhibitor of the sodium-calcium exchanger (NCX), with IC50 values of 67 nM for reverse mode inhibition and 55 nM for forward mode inhibition.

ORM-10962

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Catalog No. T12322Cas No. 763926-98-3

ORM-10962 is a potent and highly selective inhibitor of the sodium-calcium exchanger (NCX), with IC50 values of 67 nM for reverse mode inhibition and 55 nM for forward mode inhibition.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

ORM-10962 is a potent and highly selective inhibitor of the sodium-calcium exchanger (NCX), with IC50 values of 67 nM for reverse mode inhibition and 55 nM for forward mode inhibition.

Chemical Properties

Molecular Weight	459.54
Formula	C₂₇H₂₉N₃O₄
Cas No.	763926-98-3
Smiles	OC1CCN(CC(=O)Nc2ccc(Oc3ccc4OC(CCc4c3)c3ccccc3)nc2)CC1
Relative Density.	1.280 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (544.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1761 mL	10.8804 mL	21.7609 mL	108.8045 mL
5 mM	0.4352 mL	2.1761 mL	4.3522 mL	21.7609 mL
10 mM	0.2176 mL	1.0880 mL	2.1761 mL	10.8804 mL
20 mM	0.1088 mL	0.5440 mL	1.0880 mL	5.4402 mL
50 mM	0.0435 mL	0.2176 mL	0.4352 mL	2.1761 mL
100 mM	0.0218 mL	0.1088 mL	0.2176 mL	1.0880 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc