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ORM-10962

Name: ORM-10962
Brand: TargetMol
SKU: T12322
Rating: 4.5 (1 reviews)

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Catalog No. T12322Cas No. 763926-98-3

ORM-10962 is a potent and highly selective inhibitor of the sodium-calcium exchanger (NCX), with IC50 values of 67 nM for reverse mode inhibition and 55 nM for forward mode inhibition.

ORM-10962

😃Good

Catalog No. T12322Cas No. 763926-98-3

ORM-10962 is a potent and highly selective inhibitor of the sodium-calcium exchanger (NCX), with IC50 values of 67 nM for reverse mode inhibition and 55 nM for forward mode inhibition.

Pack Size	Price	Availability
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description

ORM-10962 is a potent and highly selective inhibitor of the sodium-calcium exchanger (NCX), with IC50 values of 67 nM for reverse mode inhibition and 55 nM for forward mode inhibition.

Chemical Properties

Molecular Weight	459.54
Formula	C₂₇H₂₉N₃O₄
Cas No.	763926-98-3
Relative Density.	1.280 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (544.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1761 mL	10.8804 mL	21.7609 mL	108.8045 mL
5 mM	0.4352 mL	2.1761 mL	4.3522 mL	21.7609 mL
10 mM	0.2176 mL	1.0880 mL	2.1761 mL	10.8804 mL
20 mM	0.1088 mL	0.5440 mL	1.0880 mL	5.4402 mL
50 mM	0.0435 mL	0.2176 mL	0.4352 mL	2.1761 mL
100 mM	0.0218 mL	0.1088 mL	0.2176 mL	1.0880 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc