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AVI-4206
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Catalog No. T212376
AVI-4206 is a selective Mac1 inhibitor with an IC50 of 64 nM for inhibiting Mac1's catalytic activity. It effectively reduces SARS-CoV-2 viral replication, restores interferon response, and demonstrates survival benefits in animal models infected with SARS-CoV-2. AVI-4206 is applicable for research related to SARS-CoV-2 infections.
AVI-4206
AVI-4206
😃Good
Catalog No. T212376
AVI-4206 is a selective Mac1 inhibitor with an IC50 of 64 nM for inhibiting Mac1's catalytic activity. It effectively reduces SARS-CoV-2 viral replication, restores interferon response, and demonstrates survival benefits in animal models infected with SARS-CoV-2. AVI-4206 is applicable for research related to SARS-CoV-2 infections.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AVI-4206 is a selective Mac1 inhibitor with an IC50 of 64 nM for inhibiting Mac1's catalytic activity. It effectively reduces SARS-CoV-2 viral replication, restores interferon response, and demonstrates survival benefits in animal models infected with SARS-CoV-2. AVI-4206 is applicable for research related to SARS-CoV-2 infections. |
| In vitro | AVI-4206 inhibits the catalytic activity of Mac1 in PARP10 self-ADP-ribosylation and coupled NudT5/AMP-Glo assays, with an IC50 of 64 nM within concentrations of 0.1-1000000 nM. It binds with high efficiency and selectivity to Mac1 in A549 cells at 10 μM. However, AVI-4206 shows limited efficacy in SARS-CoV-2 infected Vero-TMPRSS2 or A549-ACE2h cells at concentrations ranging from 0.01-10000 nM. In addition, AVI-4206 at concentrations of 0.16-100 μM over 24-72 hours reduces viral particle production following infection by a Mac1 deletion virus (WA1 N40D mutant). |
| In vivo | AVI-4206, administered intraperitoneally at a dose of 100 mg/kg twice daily for 7 consecutive days, demonstrates efficacy in the K18-hACE2 mouse model of SARS-CoV-2 infection. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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