APTSTAT3-9R acetate

Name: APTSTAT3-9R acetate
Brand: TargetMol
SKU: TP2222L
Rating: 4.5 (1 reviews)

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Catalog No. TP2222L

APTSTAT3-9R acetate is a selective peptide binding STAT3 with antiproliferative and antitumor activity. APTSTAT3-9R acetate and inhibits STAT3 activation and downstream signaling by specifically blocking STAT3 phosphorylation.

APTSTAT3-9R acetate

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Catalog No. TP2222L

Pack Size	Price	Availability
1 mg	$227	Backorder
5 mg	$677	Backorder
10 mg	$997	Backorder
25 mg	$1,827	Backorder
50 mg	$2,742	Backorder
100 mg	$4,113	Backorder

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Product Introduction

Bioactivity

Description	APTSTAT3-9R acetate is a selective peptide binding STAT3 with antiproliferative and antitumor activity. APTSTAT3-9R acetate and inhibits STAT3 activation and downstream signaling by specifically blocking STAT3 phosphorylation.
In vitro	APTSTAT3-9R acetate (7.5, 15, and 30 μmol/L) significantly reduces STAT3–DNA-binding activity in a dose-dependent manner in human lung carcinoma cells (A549) but does not affect the level of AKT phosphorylation, indicating specificity of the aptide. APTSTAT3-9R acetate (30 μM) suppresses cell viability and proliferation of cancer cells and significantly suppresses colony formation. The IC50s are 10 to 20 μM in A549, B16F1, and HepG2 cells[1].
In vivo	In female BALB/c nude mice with A549 cells, APTSTAT3-9R acetate (8 mg/kg in 50 μL; intratumoral injection) suppresses tumor growth[1].

Chemical Properties

Molecular Weight	5007.56
Formula	C₂₂₅H₃₃₄N₈₀O₅₃
Sequence	His-Gly-Phe-Gln-Trp-Pro-Gly-Ser-Trp-xiThr-Trp-Glu-Asn-Gly-Lys-Trp-xiThr-Trp-Lys-Gly-Ala-Tyr-Gln-Phe-Leu-Lys-Gly-Gly-Gly-Gly-Ser-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg
Sequence Short	HGFQWPGSWXWENGKWXWKGAYQFLKGGGGSRRRRRRRRR

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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