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Cericlamine

Name: Cericlamine
Brand: TargetMol
SKU: T68040
Price: 130 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T68040Cas No. 112922-55-1

Cericlamine is a selective 5-hydroxytryptamine (5-HT) reuptake blocker with antidepressant activity.

Cericlamine

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Purity: 99.06%

Catalog No. T68040Cas No. 112922-55-1

Cericlamine is a selective 5-hydroxytryptamine (5-HT) reuptake blocker with antidepressant activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$130	In Stock	In Stock
5 mg	$320	In Stock	In Stock
10 mg	$480	In Stock	In Stock
25 mg	$786	In Stock	In Stock
50 mg	$1,080	In Stock	In Stock
100 mg	$1,480	In Stock	In Stock
500 mg	$2,960	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.06%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

Cericlamine is a selective 5-hydroxytryptamine (5-HT) reuptake blocker with antidepressant activity.

In vivo

Cericlamine was injected for 2 weeks at a dose (16 mg/kg i.p., twice daily) that ensured complete prevention of 4-methyl-alpha-ethyl-meta-tyramine-induced depletion of brain serotonin. In vitro binding and quantitative autoradiographic studies showed that neither 5-HT1A, 5-HT2A, 5-HT2C nor 5-HT3 receptor binding sites in various brain areas were affected by the 14-day treatment with cericlamine. Although forskolin-stimulated adenylate cyclase activity was significantly increased in hippocampal homogenates from cericlamine-treated rats, the reduction in this enzymatic activity due to 5-HT1A receptor stimulation by 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) was unchanged in these animals as compared with controls. Thus the potency of 8-OH-DPAT and ipsapirone to depress the firing rate of these neurons in brain stem slices was significantly reduced after the 2-week treatment with cericlamine. In vivo, the potency of an injection of cericlamine to inhibit the discharge of serotoninergic neurons was also markedly less in rats that had been pretreated for 2 weeks with this drug as compared with controls.[1]

Chemical Properties

Molecular Weight	262.18
Formula	C₁₂H₁₇Cl₂NO
Cas No.	112922-55-1
Smiles	C(CC1=CC(Cl)=C(Cl)C=C1)(N(C)C)(CO)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (171.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8142 mL	19.0709 mL	38.1417 mL	190.7087 mL
5 mM	0.7628 mL	3.8142 mL	7.6283 mL	38.1417 mL
10 mM	0.3814 mL	1.9071 mL	3.8142 mL	19.0709 mL
20 mM	0.1907 mL	0.9535 mL	1.9071 mL	9.5354 mL
50 mM	0.0763 mL	0.3814 mL	0.7628 mL	3.8142 mL
100 mM	0.0381 mL	0.1907 mL	0.3814 mL	1.9071 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc