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BAY-598

Name: BAY-598
Brand: TargetMol
SKU: T7403
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7403Cas No. 1906919-67-2

BAY 598 is a potent and selective competitive inhibitor of SMYD2 lysine methyltransferase, IC50 values are 27 and 58 nM for biochemical and cellular activity assays, respectively.

BAY-598

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Purity: 99.78%

Catalog No. T7403Cas No. 1906919-67-2

BAY 598 is a potent and selective competitive inhibitor of SMYD2 lysine methyltransferase, IC50 values are 27 and 58 nM for biochemical and cellular activity assays, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$43	In Stock	In Stock
5 mg	$88	In Stock	In Stock
10 mg	$142	In Stock	In Stock
25 mg	$263	In Stock	In Stock
50 mg	$428	In Stock	In Stock
100 mg	$645	-	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.78%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	BAY 598 is a potent and selective competitive inhibitor of SMYD2 lysine methyltransferase, IC50 values are 27 and 58 nM for biochemical and cellular activity assays, respectively.
Targets&IC50	SMYD2:27 nM
In vitro	METHODS: PDAC cells SW1990 and MIA PaCa2 were treated with BAY-598 (10 µM) and doxorubicin (1 µM) for 48 h. Cell viability was determined by MTT assay. RESULTS: PDAC cells were highly sensitive to acute treatment with the low-dose combination of doxorubicin and BAY-598. [1]
In vivo	METHODS: To detect antitumor activity in vivo, BAY-598 (50 mg/kg once daily) and gemcitabine (100 mg/kg every three days) were administered intraperitoneally to NSG mice bearing SW1990 xenografts for 27 days. RESULTS: The combination of gemcitabine and BAY-598 attenuated the growth of SW1990 xenografts compared to monotherapy. [1] METHODS: To assay anti-tumor activity in vivo, BAY-598 (10-100 mg/kg, PEG 400/water 8:2) was administered orally to BALB/c nude mice bearing KYSE-150 xenografts once daily for three days. RESULTS: BAY-598 was able to inhibit SMYD2 methylation activity in tumor cells in vivo. [2]

Chemical Properties

Molecular Weight	525.34
Formula	C₂₂H₂₀Cl₂F₂N₆O₃
Cas No.	1906919-67-2
Smiles	CCN([C@H]1CN(N=C1c1ccc(Cl)c(Cl)c1)C(\NC#N)=N\c1cccc(OC(F)F)c1)C(=O)CO
Relative Density.	1.46 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (237.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9035 mL	9.5176 mL	19.0353 mL	95.1765 mL
5 mM	0.3807 mL	1.9035 mL	3.8071 mL	19.0353 mL
10 mM	0.1904 mL	0.9518 mL	1.9035 mL	9.5176 mL
20 mM	0.0952 mL	0.4759 mL	0.9518 mL	4.7588 mL
50 mM	0.0381 mL	0.1904 mL	0.3807 mL	1.9035 mL
100 mM	0.0190 mL	0.0952 mL	0.1904 mL	0.9518 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc