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Cyclotriazadisulfonamide hydrochloride

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Catalog No. T39264LCas No. 392287-03-5
Alias Cyclotriazadisulfonamide hydrochloride (182316-44-5 Free base)

Cyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way.

Cyclotriazadisulfonamide hydrochloride
Other Forms of Cyclotriazadisulfonamide hydrochloride:
CyclotriazadisulfonamideT39264182316-44-5
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Cyclotriazadisulfonamide hydrochloride

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Catalog No. T39264LAlias Cyclotriazadisulfonamide hydrochloride (182316-44-5 Free base)Cas No. 392287-03-5
Cyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$195InquiryInquiry
5 mg$437InquiryInquiry
10 mg$655InquiryInquiry
25 mg$1,178InquiryInquiry
50 mg$1,768InquiryInquiry
100 mg$2,652InquiryInquiry
200 mg$3,978InquiryInquiry
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Cyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way.
In vitro
Cyclotriazadisulfonamide hydrochloride exhibits an EC50 of 0.4 μg/mL for CD4 in MO-DC cells. Cyclotriazadisulfonamide hydrochloride (10 μg/mL) results in 83% downregulation of cell surface CD4. Cyclotriazadisulfonamide hydrochloride prevents MT-4 cells from HIV-1 and SIV infection with EC50s of 0.7 and 1.2 g/ml, respectively. Cyclotriazadisulfonamide hydrochloride significantly decreases the amount of cell surface CD4 -the main receptor for HIV -without altering the expression of any other cellular receptor examined so far[1].
SynonymsCyclotriazadisulfonamide hydrochloride (182316-44-5 Free base)
Chemical Properties
Molecular Weight618.25
FormulaC31H40ClN3O4S2
Cas No.392287-03-5
SmilesCC1=CC=C(S(=O)(N(CCCN(CC2=CC=CC=C2)CCCN(S(C3=CC=C(C=C3)C)(=O)=O)C4)CC4=C)=O)C=C1.Cl
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

HIVProteaseHIV ProteaseHIVCyclotriazadisulfonamide hydrochloride182316-44-5 Free base182316-44-5
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