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Ro 25-6981

🥰Excellent
Catalog No. T12758Cas No. 169274-78-6

Ro 25-6981 is a potent and selective activity-dependent NMDA receptors blocker containing the NR2B subunit with IC50s of 0.009 and 52 μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively. Ro 25-6981 can be used in studies about Parkinson's disease.

Ro 25-6981
Other Forms of Ro 25-6981:

Ro 25-6981

🥰Excellent
Purity: 99.88%
Catalog No. T12758Cas No. 169274-78-6
Ro 25-6981 is a potent and selective activity-dependent NMDA receptors blocker containing the NR2B subunit with IC50s of 0.009 and 52 μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively. Ro 25-6981 can be used in studies about Parkinson's disease.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$35In StockIn Stock
5 mg$78In StockIn Stock
10 mg$113In StockIn Stock
25 mg$188In StockIn Stock
1 mL x 10 mM (in DMSO)$86In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.88%
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Product Introduction

Bioactivity
Description
Ro 25-6981 is a potent and selective activity-dependent NMDA receptors blocker containing the NR2B subunit with IC50s of 0.009 and 52 μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively. Ro 25-6981 can be used in studies about Parkinson's disease.
In vivo
Ro 25-6981 (800 µg; intrathecally) shows significant analgesic effects on incision pain in rats and effectively attenuates postoperative hyperalgesia induced by remifentanil[3]. In 6-OHDA-lesioned rats, Ro 25-6981 (0.39-12.5 mg/kg; i.p.) dose-dependently induces contraversive rotations without stimulating locomotion in normal rats[4]. In male albino rats of Wistar strain, Ro 25-6981 (1 and 3 mg/kg; i.p.) exhibits activation- and age-dependent anticonvulsant action at early postnatal development and causes a significant decrease of N1–P2 amplitude at higher stimulation intensities at 3 mg/kg[5].
Chemical Properties
Molecular Weight339.47
FormulaC22H29NO2
Cas No.169274-78-6
SmilesC[C@@H](CN1CCC(Cc2ccccc2)CC1)[C@@H](O)c1ccc(O)cc1
Relative Density.1.116 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 90 mg/mL (265.12 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.72 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9458 mL14.7288 mL29.4577 mL147.2884 mL
5 mM0.5892 mL2.9458 mL5.8915 mL29.4577 mL
10 mM0.2946 mL1.4729 mL2.9458 mL14.7288 mL
20 mM0.1473 mL0.7364 mL1.4729 mL7.3644 mL
50 mM0.0589 mL0.2946 mL0.5892 mL2.9458 mL
100 mM0.0295 mL0.1473 mL0.2946 mL1.4729 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Keywords

Ro 25-6981Ro 256981Ro 25 6981NR2B-NMDA
Related Tags: buy Ro 25-6981 | purchase Ro 25-6981 | Ro 25-6981 cost | order Ro 25-6981 | Ro 25-6981 chemical structure | Ro 25-6981 in vivo | Ro 25-6981 formula | Ro 25-6981 molecular weight
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