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SK33

Name: SK33
Brand: TargetMol
SKU: T12928
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12928Cas No. 1928724-23-5

SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.

SK33

🥰Excellent

Purity: 99.55%

Catalog No. T12928Cas No. 1928724-23-5

SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$68	In Stock
10 mg	$118	In Stock
25 mg	$236	In Stock
50 mg	$378	In Stock
100 mg	$612	In Stock
200 mg	$867	In Stock
1 mL x 10 mM (in DMSO)	$97	In Stock

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Batch Information

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Purity:99.55%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.
Targets&IC50	LNCaPAR+ cells:0.2 μM
In vitro	SK33 has a significantly potent activity (IC50:0.2 μM) in LNCaPAR+ cells. SK33 decreases cells enter S-phase in LNCaP cells. In LNCaP/BicR cells, increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth(IC50 : 5 μM for SK33).
In vivo	AR transcriptional activity inhibited by SK33 after 50 mg/kg treatment for 24 hours.

Chemical Properties

Molecular Weight	500.31
Formula	C₂₀H₁₃F₉N₂O₃
Cas No.	1928724-23-5
Smiles	CC(O)(COc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F
Relative Density.	1.53 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (109.93 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9988 mL	9.9938 mL	19.9876 mL	99.9380 mL
5 mM	0.3998 mL	1.9988 mL	3.9975 mL	19.9876 mL
10 mM	0.1999 mL	0.9994 mL	1.9988 mL	9.9938 mL
20 mM	0.0999 mL	0.4997 mL	0.9994 mL	4.9969 mL
50 mM	0.0400 mL	0.1999 mL	0.3998 mL	1.9988 mL
100 mM	0.0200 mL	0.0999 mL	0.1999 mL	0.9994 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc