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STL001
(Synonyms: STL-001, STL 001) Copy Product Info
🥰Excellent
Synonyms: STL-001, STL 001
Catalog No. T209895 Copy Product Info
Purity: 99.97%
🥰Excellent
STL001 is a potent and highly selective inhibitor of FOXM1. It induces the translocation of FOXM1 from the nucleus to the cytoplasm and promotes its degradation via the autophagic pathway. Additionally, STL001 enhances the sensitivity of human cancers to various cancer therapies.
Cas No. 3047493-70-6
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $132 | - | In Stock | |
| 5 mg | $332 | - | In Stock | |
| 10 mg | $539 | - | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,740 | - | In Stock | |
| 100 mg | $2,780 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.97%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | STL001 is a potent and highly selective inhibitor of FOXM1. It induces the translocation of FOXM1 from the nucleus to the cytoplasm and promotes its degradation via the autophagic pathway. Additionally, STL001 enhances the sensitivity of human cancers to various cancer therapies. |
| In vitro | Method: Human ovarian cancer (OVCAR-8, ES-2), colorectal cancer (HCT-116, HCT-FET), esophageal cancer (FLO-1), breast cancer (TAM-R, HCC-1143), and prostate cancer (22Rv1, LNCaP) cells were treated with STL001 (1, 5, 10 μM) for 24 h. FOXM1 protein expression levels were detected by Western Blot. Result: STL001 dose-dependently reduced FOXM1 protein levels in the above cells, with significant effects observed at 1 μM, and was 25-50 times more efficient than its parental compound STL427944 [1]. Method: Human esophageal cancer FLO-1 cells and U2OS C3-luc cells expressing EGFP-FOXM1 fusion protein were treated with STL001 (5 or 10 μM) in combination with chloroquine or leptomycin B for 24 h. FOXM1 and LC3 expression were detected by Western Blot. Result: STL001 induced the translocation of nuclear FOXM1 to the cytoplasm and promoted its autophagic degradation. Chloroquine (an inhibitor of autophagosome-lysosome fusion) reversed this effect, and leptomycin B (a nuclear export inhibitor) also blocked STL001-induced FOXM1 suppression [1]. |
| Synonyms | STL-001, STL 001 |
| Molecular Weight | 509.52 |
| Formula | C27H23N7O4 |
| Cas No. | 3047493-70-6 |
| Smiles | O=C(OC1=CC=CC(=C1)C2=NN(C=C2)C3=NC(=NC(=N3)N4CCOCC4)NC=5C=CC=CC5)C=6OC=CC6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 4 mg/mL (7.85 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: STL001 chemical structure | STL001 in vitro | STL001 formula | STL001 molecular weight
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