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EMD386088

Name: EMD386088
Brand: TargetMol
SKU: T212627
Rating: 4.5 (1 reviews)

🥰Excellent

Catalog No. T212627Cas No. 54635-62-0

Alias EMD-386088, EMD 386088

EMD386088 is a potent and selective 5-HT6 receptor agonist with nanomolar efficacy that displays minimal off-target activity across other serotonin receptor subtypes, except limited interaction with 5-HT3R, EMD386088 modulates ERK1/2 signaling pathways, supporting its utility in mechanistic research related to Alzheimer’s disease and schizophrenia.

EMD386088

🥰Excellent

Catalog No. T212627Alias EMD-386088, EMD 386088Cas No. 54635-62-0

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Product Introduction

Bioactivity

Description	EMD386088 is a potent and selective 5-HT6 receptor agonist with nanomolar efficacy that displays minimal off-target activity across other serotonin receptor subtypes, except limited interaction with 5-HT3R, EMD386088 modulates ERK1/2 signaling pathways, supporting its utility in mechanistic research related to Alzheimer’s disease and schizophrenia.
Synonyms	EMD-386088, EMD 386088

Chemical Properties

Molecular Weight	246.74
Formula	C₁₄H₁₅ClN₂
Cas No.	54635-62-0
Smiles	ClC1=CC=C2NC(=C(C2=C1)C3=CCNCC3)C

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (324.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0528 mL	20.2642 mL	40.5285 mL	202.6425 mL
5 mM	0.8106 mL	4.0528 mL	8.1057 mL	40.5285 mL
10 mM	0.4053 mL	2.0264 mL	4.0528 mL	20.2642 mL
20 mM	0.2026 mL	1.0132 mL	2.0264 mL	10.1321 mL
50 mM	0.0811 mL	0.4053 mL	0.8106 mL	4.0528 mL
100 mM	0.0405 mL	0.2026 mL	0.4053 mL	2.0264 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc