HSK0935

Name: HSK0935
Brand: TargetMol
SKU: T15505
Rating: 4.5 (1 reviews)

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Catalog No. T15505Cas No. 1638851-44-1

Alias HSK-0935, HSK 0935

HSK0935 is a highly selective and orally available SGLT2 inhibitor (IC50: 1.3 nM). It has antihyperglycemic activities.

HSK0935

😃Good

Catalog No. T15505Alias HSK-0935, HSK 0935Cas No. 1638851-44-1

HSK0935 is a highly selective and orally available SGLT2 inhibitor (IC50: 1.3 nM). It has antihyperglycemic activities.

Pack Size	Price	Availability
25 mg	$1,420	6-8 weeks
50 mg	$1,850	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	HSK0935 is a highly selective and orally available SGLT2 inhibitor (IC50: 1.3 nM). It has antihyperglycemic activities.
Targets&IC50	SGLT2:1.3 nM
In vitro	HSK0935 shows excellent hSGLT2 inhibition of 1.3 nM. HSK0935 displays a high hSGLT1/hSGLT2 selectivity of 843-fold[1].
In vivo	In a 28-day repeat-dose toxicology study conducted on beagle dogs, HSK0935 was found to be well-tolerated at doses up to 300 mg/kg, without causing any deaths or severe adverse effects. Additionally, treatment with HSK0935 at doses of 1, 3, and 10 mg/kg resulted in significant urinary glucose excretion in Sprague-Dawley (SD) rats, and had an even greater effect on urinary glucose excretion in Rhesus monkeys[1].
Synonyms	HSK-0935, HSK 0935

Chemical Properties

Molecular Weight	436.88
Formula	C₂₂H₂₅ClO₇
Cas No.	1638851-44-1
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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