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Belumosudil mesylate

Name: Belumosudil mesylate
Brand: TargetMol
SKU: T39555
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T39555Cas No. 2109704-99-4

Alias SLx-2119 mesylate, SLx2119 mesylate, SAR445761, Rezurock Rezurock, KD025 mesylate, KD 025 mesylate

Belumosudil mesylate (KD025 mesylate) is a selective and highly efficient ROCK2 inhibitor with antifibrotic activity. It inhibits ROCK1 and can be used in chronic graft-versus-host disease research.

Belumosudil mesylate

🥰Excellent

Purity: 98.73%

Catalog No. T39555Alias SLx-2119 mesylate, SLx2119 mesylate, SAR445761, Rezurock Rezurock, KD025 mesylate, KD 025 mesylateCas No. 2109704-99-4

Belumosudil mesylate (KD025 mesylate) is a selective and highly efficient ROCK2 inhibitor with antifibrotic activity. It inhibits ROCK1 and can be used in chronic graft-versus-host disease research.

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$68	In Stock
10 mg	$98	In Stock
25 mg	$182	In Stock
50 mg	$268	In Stock
100 mg	$396	In Stock
200 mg	$589	In Stock
1 mL x 10 mM (in DMSO)	$86	In Stock

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Purity:98.73%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Belumosudil mesylate (KD025 mesylate) is a selective and highly efficient ROCK2 inhibitor with antifibrotic activity. It inhibits ROCK1 and can be used in chronic graft-versus-host disease research.
Targets&IC50	ROCK2:105 nM (IC50), ROCK1:24 μM (IC50)
In vitro	Belumosudil mesylate is a selective inhibitor of ROCK2, with IC50s of 105 nM and 24 μM for ROCK2 and ROCK1, respectively.[1] 40 μM Belumosudil mesylate significantly down-regulated the levels of Tsp-1 and CTGF mRNA in pulmonary artery smooth muscle cells (PASMC). [1]
In vivo	Intraperitoneal injection of 100, 200, or 300 mg/kg Belumosudil mesylate dose-dependently reduced infarct volume after transient middle cerebral artery occlusion. Belumosudil mesylate was at least as effective in aged, diabetic, or female mice as in normal adult male mice. [2]
Synonyms	SLx-2119 mesylate, SLx2119 mesylate, SAR445761, Rezurock Rezurock, KD025 mesylate, KD 025 mesylate

Chemical Properties

Molecular Weight	548.61
Formula	C₂₇H₂₈N₆O₅S
Cas No.	2109704-99-4
Smiles	O=C(NC(C)C)COC1=CC=CC(=C1)C=2N=C3C=CC=CC3=C(N2)NC=4C=CC=5NN=CC5C4.O=S(=O)(O)C

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 1 mg/mL (1.82 mM), Sonication and heating are recommended.

DMSO: 20 mg/mL (36.46 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8228 mL	9.1139 mL	18.2279 mL	91.1394 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.3646 mL	1.8228 mL	3.6456 mL	18.2279 mL
10 mM	0.1823 mL	0.9114 mL	1.8228 mL	9.1139 mL
20 mM	0.0911 mL	0.4557 mL	0.9114 mL	4.5570 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc