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ML289

Name: ML289
Brand: TargetMol
SKU: T23000
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23000Cas No. 1382481-79-9

Alias VU0463597, ML 289

ML289 (VU0463597) is a potent, selective, and CNS-penetrant negative allosteric modulator of mGlu3 (IC50=0.66 μM), with over 15-fold selectivity compared to mGlu2 and no activity against mGlu5.

ML289

🥰Excellent

Purity: 99.54%

Catalog No. T23000Alias VU0463597, ML 289Cas No. 1382481-79-9

ML289 (VU0463597) is a potent, selective, and CNS-penetrant negative allosteric modulator of mGlu3 (IC50=0.66 μM), with over 15-fold selectivity compared to mGlu2 and no activity against mGlu5.

Pack Size	Price	Availability
5 mg	$43	In Stock
10 mg	$73	In Stock
25 mg	$148	In Stock
50 mg	$236	In Stock
100 mg	$356	In Stock
200 mg	$495	In Stock
1 mL x 10 mM (in DMSO)	$47	In Stock

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Purity:99.54%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	ML289 (VU0463597) is a potent, selective, and CNS-penetrant negative allosteric modulator of mGlu3 (IC50=0.66 μM), with over 15-fold selectivity compared to mGlu2 and no activity against mGlu5.
Targets&IC50	mGluR3:0.66 μM (IC50)
In vitro	ML289 (VU0463597) is a central nervous system (CNS)-penetrant probe that functions as a negative allosteric modulator of the metabotropic glutamate receptor 3 (mGlu3)[1].
Synonyms	VU0463597, ML 289

Chemical Properties

Molecular Weight	349.42
Formula	C₂₂H₂₃NO₃
Cas No.	1382481-79-9
Smiles	COc1ccc(cc1)C#Cc1ccc(cc1)C(=O)N1CCC[C@@H](CO)C1
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (643.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8619 mL	14.3094 mL	28.6189 mL	143.0943 mL
5 mM	0.5724 mL	2.8619 mL	5.7238 mL	28.6189 mL
10 mM	0.2862 mL	1.4309 mL	2.8619 mL	14.3094 mL
20 mM	0.1431 mL	0.7155 mL	1.4309 mL	7.1547 mL
50 mM	0.0572 mL	0.2862 mL	0.5724 mL	2.8619 mL
100 mM	0.0286 mL	0.1431 mL	0.2862 mL	1.4309 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc