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Ro 41-1049 hydrochloride

Name: Ro 41-1049 hydrochloride
Brand: TargetMol
SKU: T16770
Rating: 4.5 (1 reviews)

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Catalog No. T16770Cas No. 127917-66-2

Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (Kd: 16.5 and 64.4 nM, respectively).

Ro 41-1049 hydrochloride

😃Good

Catalog No. T16770Cas No. 127917-66-2

Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (Kd: 16.5 and 64.4 nM, respectively).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$38	5 days	5 days
5 mg	$59	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$63	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (Kd: 16.5 and 64.4 nM, respectively).

In vivo

Ro 41-1049 (20 mg/kg) pretreatment significantly increases dopamine formation following L-dopa administration (100 mg/kg IP) while decreasing the formation of 3,4-dihydroxyphenylacetic acid and homovanillic acid. Ro 41-1049 (1-50 mg/kg; intraperitoneal injection; for 3 hours; Sprague-Dawley rats) treatment inhibits dopamine metabolite formation and increases dopamine levels in a dose-dependent fashion [2].

Chemical Properties

Molecular Weight	301.77
Formula	C₁₂H₁₃ClFN₃OS
Cas No.	127917-66-2
Smiles	Cl.NCCNC(=O)c1ncsc1-c1cccc(F)c1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 32 mg/mL (106.04 mM), Sonication is recommended.

H2O: 25 mg/mL (82.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (6.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3138 mL	16.5689 mL	33.1378 mL	165.6891 mL
5 mM	0.6628 mL	3.3138 mL	6.6276 mL	33.1378 mL
10 mM	0.3314 mL	1.6569 mL	3.3138 mL	16.5689 mL
20 mM	0.1657 mL	0.8284 mL	1.6569 mL	8.2845 mL
50 mM	0.0663 mL	0.3314 mL	0.6628 mL	3.3138 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0331 mL	0.1657 mL	0.3314 mL	1.6569 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc