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Ro 41-1049 hydrochloride

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Catalog No. T16770Cas No. 127917-66-2

Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (Kd: 16.5 and 64.4 nM, respectively).

Ro 41-1049 hydrochloride
Other Forms of Ro 41-1049 hydrochloride:
Ro 41-1049T28587127500-84-9
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Ro 41-1049 hydrochloride

😃Good
Catalog No. T16770Cas No. 127917-66-2
Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (Kd: 16.5 and 64.4 nM, respectively).
Pack SizePriceAvailabilityQuantity
2 mg$385 days
5 mg$597-10 days
1 mL x 10 mM (in DMSO)$637-10 days
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Product Introduction

Bioactivity
Description
Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (Kd: 16.5 and 64.4 nM, respectively).
In vivo
Ro 41-1049 (20 mg/kg) pretreatment significantly increases dopamine formation following L-dopa administration (100 mg/kg IP) while decreasing the formation of 3,4-dihydroxyphenylacetic acid and homovanillic acid. Ro 41-1049 (1-50 mg/kg; intraperitoneal injection; for 3 hours; Sprague-Dawley rats) treatment inhibits dopamine metabolite formation and increases dopamine levels in a dose-dependent fashion [2].
Chemical Properties
Molecular Weight301.77
FormulaC12H13ClFN3OS
Cas No.127917-66-2
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 32 mg/mL (106.04 mM), Sonication is recommended.
H2O: 25 mg/mL (82.84 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM3.3138 mL16.5689 mL33.1378 mL165.6891 mL
5 mM0.6628 mL3.3138 mL6.6276 mL33.1378 mL
10 mM0.3314 mL1.6569 mL3.3138 mL16.5689 mL
20 mM0.1657 mL0.8284 mL1.6569 mL8.2845 mL
50 mM0.0663 mL0.3314 mL0.6628 mL3.3138 mL
DMSO
1mg5mg10mg50mg
100 mM0.0331 mL0.1657 mL0.3314 mL1.6569 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Ro 41-1049 HydrochlorideRo 411049 hydrochlorideRo 41 1049 hydrochlorideMAO-A
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